Evidence map›Paper›PMID 30242899›Full record

ArticleMagnetic resonance in medicine2019

Multi-modal functional MRI to explore placental function over gestation.

Jana Hutter, Paddy J Slator, Laurence Jackson, Ana Dos Santos Gomes, Alison Ho, Lisa Story, Jonathan O'Muircheartaigh, Rui P A G Teixeira, Lucy C Chappell, Daniel C Alexander and 2 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Characterizing fetoplacental response to acute maternal hyperoxygenation in suspected coarctation of aorta using fetal cardiac MRI.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
  7. Toward Clinical Implementation of Magnetic Resonance Imaging for Placental Function.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Review
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Functional MRI assessment of the lungs in fetuses that deliver very Preterm: An MRI pilot study.European journal of obstetrics, gynecology, and reproductive biology · 2024
    Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jana HutterCentre for the Developing Brain, King's College London, United Kingdom.
Paddy J SlatorBiomedical Engineering Department, King's College London, United Kingdom.
Laurence JacksonCentre for the Developing Brain, King's College London, United Kingdom.
Ana Dos Santos GomesCentre for the Developing Brain, King's College London, United Kingdom.
Alison HoWomen's Health Academic Centre, King's College London, London, United Kingdom.
Lisa StoryCentre for the Developing Brain, King's College London, United Kingdom.
Jonathan O'MuircheartaighCentre for the Developing Brain, King's College London, United Kingdom.
Rui P A G TeixeiraCentre for the Developing Brain, King's College London, United Kingdom.
Lucy C ChappellWomen's Health Academic Centre, King's College London, London, United Kingdom.
Daniel C AlexanderCentre for Medical Image Computing and Department of Computer Science, University College London, United Kingdom.
Mary A RutherfordCentre for the Developing Brain, King's College London, United Kingdom.
Joseph V HajnalCentre for the Developing Brain, King's College London, United Kingdom.

Funding

Structure and function of the placenta from implantation to delivery: a next generation MRI approachU01HD087202 · NICHD · KING'S COLLEGE LONDON · PI ALEXANDER, DANIEL, ALJABAR, PAUL · 2015 to 2015
$3.2M
Department of Health RP-2014-05-019European Research Council 319456Medical Research Council MR/K006355/1NICHD NIH HHS U01 HD087202Wellcome Trust 201374/Z/16/ZWellcome Trust 203148/Z/16/Z
6 · The paper itself

Abstract

purposeTo investigate, visualize and quantify the physiology of the human placenta in several dimensions - functional, temporal over gestation, and spatial over the whole organ.

methodsBespoke MRI techniques, combining a rich diffusion protocol, anatomical data and T2* mapping together with a multi-modal pipeline including motion correction and extracted quantitative features were developed and employed on pregnant women between 22 and 38 weeks gestational age including two pregnancies diagnosed with pre-eclampsia.

resultsA multi-faceted assessment was demonstrated showing trends of increasing lacunarity, and decreasing T2* and diffusivity over gestation.

conclusionsThe obtained multi-modal acquisition and quantification shows promising opportunities for studying evolution, adaptation and compensation processes.

Indexed as

Diffusion Magnetic Resonance ImagingAlgorithmsAnisotropyArtifactsFemaleFetusGestational AgeHumansImage Processing, Computer-AssistedLeast-Squares AnalysisModels, AnatomicMotionPlacentaPre-EclampsiaPregnancyPrenatal Diagnosisdevelopmentdiffusion MRIplacentapostprocessingpregnancy complicationsrelaxometry

Identifiers

PMID30242899
PMCPMC6585747

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.