ArticleActa psychiatrica Scandinavica2018
Long-term cognitive trajectories and heterogeneity in patients with schizophrenia and their unaffected siblings.
Article in Acta psychiatrica Scandinavica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive change 5+ years since the onset of a psychotic disorder: A systematic review and meta-analysis.Psychological medicine · 2025Pooled it
- A systematic review and narrative synthesis of data-driven studies in schizophrenia symptoms and cognitive deficits.Translational psychiatry · 2020Pooled it
- The Lived Experience of Cognitive Impairment Associated With Schizophrenia: A Conceptual Model.Schizophrenia bulletin open · 2026Article
- Interrelationships of long-term changes in recovery domains among patients with schizophrenia spectrum disorders: a six-year follow-up study.BMC psychiatry · 2025Article
- Bidirectional relationships among complex PTSD, dissociation, and psychotic symptoms in two samples.European journal of psychotraumatology · 2025Article
- Hearing voices and other altered perceptual experiences across psychotic, mood, and anxiety disorders: from phenomenology and mechanisms to future directions.Schizophrenia (Heidelberg, Germany) · 2025Review
- Neuropsychiatric symptoms in siblings of children with Tourette syndrome in the EMTICS study.JCPP advances · 2025Article
- Unmet Financial Needs of People with Psychotic Disorders-A Cross-Sectional Study in People with Psychotic Disorders, Parents, Siblings, and Controls.Journal of clinical medicine · 2024Article
- Moving from supported to independent living: what are the barriers and facilitators for individuals with psychosis?Social psychiatry and psychiatric epidemiology · 2024Article
- Utilizing Technology to Enhance the Ecological Validity of Cognitive and Functional Assessments in Schizophrenia: An Overview of the State-of-the-Art.Schizophrenia bulletin open · 2024Article
- Association of clinical symptoms and cardiometabolic dysregulations in patients with schizophrenia spectrum disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Understanding Lifelong Factors and Prediction Models of Social Functioning After Psychosis Onset Using the Large-Scale GROUP Cohort Study.Schizophrenia bulletin · 2023Article
- Deep Clinical Phenotyping of Schizophrenia Spectrum Disorders Using Data-Driven Methods: Marching towards Precision Psychiatry.Journal of personalized medicine · 2023Article
- Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment.Molecular psychiatry · 2023Review
- MICEmi: A method to identify cognitive endophenotypes of mental illnesses.European psychiatry : the journal of the Association of European Psychiatrists · 2022Review
- A subtype of institutionalized patients with schizophrenia characterized by pronounced subcortical and cognitive deficits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Lifespan evolution of neurocognitive impairment in schizophrenia - A narrative review.Schizophrenia research. Cognition · 2022Review
- Investigating data-driven biological subtypes of psychiatric disorders using specification-curve analysis.Psychological medicine · 2022Article
- OCT and OCT Angiography Offer New Insights and Opportunities in Schizophrenia Research and Treatment.Frontiers in digital health · 2022Article
- Twelve-Month Cognitive Trajectories in Individuals at Ultra-High Risk for Psychosis: A Latent Class Analysis.Schizophrenia bulletin open · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveThis study aimed to assess the heterogeneity and stability of cognition in patients with a non-affective psychotic disorder and their unaffected siblings. In addition, we aimed to predict the cognitive subtypes of siblings by their probands.
methodAssessments were conducted at baseline, 3 and 6 years in 1119 patients, 1059 siblings and 586 controls from the Genetic Risk and Outcome of Psychosis (GROUP) study. Group-based trajectory modeling was applied to identify trajectories and clustered multinomial logistic regression analysis was used for prediction modeling. A composite score of eight neurocognitive tests was used to measure cognitive performance.
resultsFive stable cognitive trajectories ranging from severely altered to high cognitive performance were identified in patients. Likewise, four stable trajectories ranging from moderately altered to high performance were found in siblings. Siblings had a higher risk of cognitive alteration when patients' alteration was mild (OR = 2.21), moderate (OR = 5.70), and severe (OR = 10.07) compared with patients with intact cognitive function. The familial correlation coefficient between pairs of index patients and their siblings was 0.27 (P = 0.003).
conclusionsThe cognitive profiles identified in the current study might be suitable as endophenotypes and could be used in future genetic studies and predicting functional and clinical outcomes.
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