ArticleProgress in biomaterials2018
Formulation and evaluation of curcumin microsponges for oral and topical drug delivery.
Article in Progress in biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Sustainable Extraction of Mangiferin From Mango Leaves Using Taguchi and Box-Behnken Optimization: Biochemical Characterization and Antioxidant Profiling.Journal of separation science · 2026Article
- Formulation and Evaluation of Microsponges-loaded Transdermal Gel for the Management of Osteoarthritis.Recent advances in inflammation & allergy drug discovery · 2025Article
- Preparation, characterisation andHeliyon · 2024Article
- Sortase A Inhibitor Protein Nanoparticle Formulations Demonstrate Antibacterial Synergy When Combined with Antimicrobial Peptides.Molecules (Basel, Switzerland) · 2023Article
- Dual Nanostructured Lipid Carriers/Hydrogel System for Delivery of Curcumin for Topical Skin Applications.Biomolecules · 2022Article
- Preparation of Curcumin-EudragitMolecules (Basel, Switzerland) · 2021Article
- Formulation and optimization of quinoa starch nanoparticles: Quality by design approach for solubility enhancement of piroxicam.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
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Authors and funding
2 authors.
Funding
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Abstract
The aim of the present study was to improve the release rate of curcumin by microsponges prepared through quasi-emulsion solvent diffusion technique using ethylcellulose and PVA as carriers. The microsponges were characterized by FTIR, DSC, XRD and SEM studies followed by determination of total drug content and entrapment efficiency. The prepared microsponges were further filled in hard gelatin capsule shell and then loaded in carbopol gel to evaluate its potential in oral and topical drug delivery. Further, it was observed from the studies on release rate that microsponges filled in hard gelatin capsule shells (batch MS4) showed 93.2% release of curcumin whereas pure curcumin filled in capsule showed only 11.7% release in 8 h study. Furthermore, the microsponges loaded in carbopol gel were evaluated for ex vivo drug deposition studies and it was found that 77.5% of the curcumin was released within 24 h. The estimated drug remained in the skin was 207.61 ± 5.03 μg/cm
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