ArticleSchmerz (Berlin, Germany)2018
[Long-term opioid therapy of non-cancer pain : Prevalence and predictors of hospitalization in the event of possible misuse].
Article in Schmerz (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- [Recommendations of the second update of the LONTS guidelines : Long-term opioid therapy for chronic noncancer pain].Schmerz (Berlin, Germany) · 2020Pooled it
- [Opioid prescriptions for insured individuals without cancer in Germany: data from the BARMER].Schmerz (Berlin, Germany) · 2025Article
- Exceeding the guideline-recommended maximum daily dose of opioids for long-term treatment of non-cancer pain in Germany - a large retrospective observational study.BMC public health · 2024Observational
- Comparison of Different Modeling Approaches for Prescription Opioid Use and Its Association With Adverse Events.American journal of epidemiology · 2023Article
- Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe.European journal of clinical pharmacology · 2023Article
- [Critical discussion of new data regarding prevalence of opioid use disorder in patients with chronic pain in Germany].Schmerz (Berlin, Germany) · 2022Review
- Trends in risky prescriptions of opioid analgesics from 2011 to 2015 in Northern Germany.Journal of psychopharmacology (Oxford, England) · 2020Article
- [And the opioid pendulum still swings between uncritical indication and overcritical restriction].Schmerz (Berlin, Germany) · 2020Article
- [How long does a long-term therapy last?]Schmerz (Berlin, Germany) · 2020Article
- [Long-term opioid use in non-cancer pain (LONTS 3)].Schmerz (Berlin, Germany) · 2020Article
- [The US opioid epidemic is threatening Germany].Schmerz (Berlin, Germany) · 2020Article
- Rate of opioid use disorder in adults who received prescription opioid pain therapy-A secondary data analysis.PloS one · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOne major concern of long-term opioid therapy (LTOT) for chronic noncancer pain (CNCP) is the risk of abuse of prescribed opioids.
objectiveTo examine the prevalence and predictors of opioid use-related hospitalizations and potential abuse of prescribed opioids by persons with LTOT for CNCP in a sample representative of the German statutory health insurance companies.
methodsRetrospective cross-sectional study in 2014. Anonymized German health claims database, including 4,028,618 insured individuals of 69 German statutory health insurances. Univariate logistic regression models to evaluate demographic and medical characteristics associated with hospital stays and a diagnosis of mental and behavioral disorders due to alcohol, opioids, tranquilizers, multiple substances and intoxications by narcotic agents in insured individuals with CNCP receiving LTOT.
resultsThe prevalence of LTOT for CNCP was 0.8%; 9.9% of these insured individuals received high-dose LTOT (≥120 morphine equivalent mg/day). The 1‑year prevalence of hospital stays with a diagnosis of mental and behavioral disorders due to alcohol, opioids, tranquilizers, multiple substances and intoxications by narcotic agents was 1.75% of persons with LTOT. These diagnoses were strongly associated with prescriptions of tranquilizers (odds ratio [OR] 3.63; 95% confidence interval [CI] 3.03; 4.36) and moderately associated with diagnosis of depression (OR 2.52; 95% CI 2.12; 3.00) and slightly associated with diagnosis of somatoform pain disorder (OR 1.89; 95% CI 1.56; 2.28) and high-dose LTOT (OR 1.81; 95% CI 1.44; 2.27). DISCUSSION: The study is in line with the recommendations of the German national guidelines on long-term opioid therapy of chronic non-cancer pain (LONTS) to avoid concomitant prescription of tranquilizers for CNCP and to carefully select and monitor patients with depression and somatoform pain disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.