ArticleHuman genetics2018
Knockout of ush2a gene in zebrafish causes hearing impairment and late onset rod-cone dystrophy.
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Article in Human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
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Who cites it
33 citing papers in PubMed, 46 citations in OpenAlex.
- The P4-phospholipid flippase Atp11a is required for maintenance of eye and ear structure in zebrafish.Journal of cell science · 2025Article
- Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration.Communications biology · 2025Article
- The Regulatory Role of miRNAs in Zebrafish Fin Regeneration.International journal of molecular sciences · 2024Article
- Retinal Ciliopathies and Potential Gene Therapies: A Focus on Human iPSC-Derived Organoid Models.International journal of molecular sciences · 2024Review
- Multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence imaging of USH2A knockout rabbits.Scientific reports · 2023Article
- Identification of a novel compound heterozygous pathogenic variant inThe Journal of international medical research · 2023Article
- Article
- Expression of the human usherin c.2299delG mutation leads to early-onset auditory loss and stereocilia disorganization.Communications biology · 2023Article
- Article
- Homozygous Knockout of Cep250 Leads to a Relatively Late-Onset Retinal Degeneration and Sensorineural Hearing Loss in Mice.Translational vision science & technology · 2023Article
- USH2A Gene Mutations in Rabbits Lead to Progressive Retinal Degeneration and Hearing Loss.Translational vision science & technology · 2023Article
- Retinal degeneration inFrontiers in cell and developmental biology · 2023Article
- Novel compound heterozygous variants in theFrontiers in cell and developmental biology · 2023Article
- Scrutinizing pathogenicity of the USH2A c.2276 G > T; p.(Cys759Phe) variant.NPJ genomic medicine · 2022Article
- Genetics, pathogenesis and therapeutic developments for Usher syndrome type 2.Human genetics · 2022Review
- The genetic and phenotypic landscapes of Usher syndrome: from disease mechanisms to a new classification.Human genetics · 2022Review
- Review
- Retinal organoids and microfluidic chip-based approaches to explore the retinitis pigmentosa with USH2A mutations.Frontiers in bioengineering and biotechnology · 2022Article
- Studies on the molecular level changes and potential resistance mechanism ofFrontiers in genetics · 2022Article
- Knockout ofBiomedicines · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 6 institutions in 3 countries.
Shanshan HanKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Xiliang LiuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Shanglun XieKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Meng GaoKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Fei LiuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Shanshan YuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Peng SunDepartment of Biomedical Engineering, Southern University of Science and Technology, Guangdong, People's Republic of China.
Changquan WangDepartment of Biomedical Engineering, Southern University of Science and Technology, Guangdong, People's Republic of China.
Stephen ArchackiCenter for Cardiovascular Genetics, Department of Molecular Cardiology, and Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Zhaojing LuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Xuebin HuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Yayun QinKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Zhen QuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Yuwen HuangKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Yuexia LvKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Jiayi TuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Jingzhen LiKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Tinsae Assefa YimerKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Tao JiangKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Zhaohui TangKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China.
Daji LuoDepartment of Medical Genetics, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, People's Republic of China. luodaji@whu.edu.cn.
Fangyi ChenDepartment of Biomedical Engineering, Southern University of Science and Technology, Guangdong, People's Republic of China. chenfy@sustc.edu.cn.
Mugen LiuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan, 430074, Hubei, People's Republic of China. lium@mail.hust.edu.cn.ORCID http://orcid.org/0000-0001-5076-8438
Huazhong University of Science and Technology · CNSouthern University of Science and Technology · CNCleveland Clinic · USHenan University of Science and Technology · CNUniversity of Macau · MOWuhan University · CN
Funding
National Natural Science Foundation of China 31471194National Natural Science Foundation of China 31571303National Natural Science Foundation of China 81500762National Natural Science Foundation of China 81670890
Abstract
Most cases of Usher syndrome type II (USH2) are due to mutations in the USH2A gene. There are no effective treatments or ideal animal models for this disease, and the pathological mechanisms of USH2 caused by USH2A mutations are still unknown. Here, we constructed a ush2a knockout (ush2a
Indexed as
Extracellular Matrix ProteinsGene Knockout TechniquesUsher SyndromesZebrafishZebrafish ProteinsAnimalsDisease Models, AnimalElectroretinographyHumansExtracellular Matrix ProteinsZebrafish Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.