ArticleInternational journal of colorectal disease2019
Appendiceal neoplasm risk associated with complicated acute appendicitis-a population based study.
Article in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review.Langenbeck's archives of surgery · 2023Pooled it
- Comparison of the efficacy and safety of antibiotic treatment and appendectomy for acute uncomplicated appendicitis: a systematic review and meta-analysis.BMC surgery · 2023Pooled it
- Antibiotic therapy for acute uncomplicated appendicitis: a systematic review and meta-analysis.International journal of colorectal disease · 2019Pooled it
- Uncomplicated and Complicated Acute Appendicitis Induce Different Cytokine Patterns.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Trial
- Prognostic factors associated with primary non-responsiveness to antibiotics and appendicitis recurrence for CT-diagnosed uncomplicated acute appendicitis: secondary analysis of two randomized clinical trials.The British journal of surgery · 2025Trial
- Beyond Appendicitis: A Retrospective Study Predicting Appendiceal Neoplasms in the Era of Non-Operative Management in Jamaica.Journal of racial and ethnic health disparities · 2026Article
- Association of Clinical and Laboratory Parameters with Appendiceal Neoplasms in Acute Appendicitis: A Single-Institution Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- ASO Author Reflections: Oncologic Considerations in the Management of Complicated Appendicitis.Annals of surgical oncology · 2026Article
- True Incidence of Appendiceal Neoplasms in Patients Presenting with Complicated Appendicitis: A Call for a Revised Management Algorithm.Annals of surgical oncology · 2026Article
- Prediction of distant metastasis and survival of appendiceal cancer patients: a SEER population-based study.Translational cancer research · 2026Article
- Perforated Appendicitis as a Herald of Appendiceal Adenocarcinoma: A Case Report and Literature Review.Cureus · 2026Article
- Article
- The risk of neoplasms in appendiceal abscess: what emergency surgeons should know.Frontiers in oncology · 2026Review
- Low-Grade Appendiceal Mucinous Neoplasm as an Incidental Finding During Cesarean Section: A Case Report.The American journal of case reports · 2025Article
- Appendicitis.Nature reviews. Disease primers · 2025Review
- Article
- Age-specific trends in colorectal, appendiceal, and anal tumour incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis.medRxiv : the preprint server for health sciences · 2025Article
- Is non-operative treatment of acute appendicitis possible: A narrative review.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2024Review
- Article
- Acute Appendicitis in the Elderly: A Nationwide Retrospective Analysis.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAppendiceal tumors are rare, but high neoplasm rates have been reported at interval appendectomy after periappendicular abscess. Non-operative management of uncomplicated acute appendicitis has shown promising results. The data on appendiceal tumor incidence and presentation among acute appendicitis patients is limited, especially in patient cohorts differentiating between uncomplicated and complicated acute appendicitis. Objective was to assess appendiceal tumor incidence and tumor association to appendicitis in patients with uncomplicated and complicated acute appendicitis.
methodsThis nationwide population-based registry study was conducted from 2007 to 2013. The Finnish Cancer Registry and the National Institute for Health Registry were used to combine data on all appendiceal tumors and acute appendicitis diagnosis with medical reports evaluated at eight study hospitals.
resultsAltogether, 840 appendiceal tumors were identified, and out of these, 504 patient reports were reviewed, including 472 patients in this study. Tumor was diagnosed at appendectomy for suspected acute appendicitis in 276 patients (58%). In the whole study, histologically acute appendicitis and tumor were both present in 53% (n = 250), and out of these, 41% (n = 102) were complicated and 59% (n = 148) uncomplicated acute appendicitis. The associated tumor risk was significantly higher in complicated acute appendicitis compared with uncomplicated cases (3.24% vs. 0.87%, p < 0.001). Overall tumor prevalence among acute appendicitis patients was 1.24%.
conclusionsAppendiceal tumor prevalence in acute appendicitis was low. Tumor risk was significantly higher in complicated acute appendicitis compared with uncomplicated acute appendicitis. The risk of missed appendiceal tumors related to antibiotic therapy of uncomplicated acute appendicitis is very low.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.