ArticleNeuroradiology2018
Abnormal changes in functional connectivity between the amygdala and frontal regions are associated with depression in Alzheimer's disease.
Article in Neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Mobile application leads to psychological improvement and correlated neuroimmune function change in subjective cognitive decline.NPJ digital medicine · 2025Article
- Medial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer's Disease.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- The mediating effect of the amygdala-frontal circuit on the association between depressive symptoms and cognitive function in Alzheimer's disease.Translational psychiatry · 2024Article
- Medial amygdalar tau is associated with anxiety symptoms in preclinical Alzheimer's disease.bioRxiv : the preprint server for biology · 2024Article
- The neural basis of neuropsychiatric symptoms in Alzheimer's disease.Frontiers in aging neuroscience · 2024Review
- Kullback-Leibler Divergence of Sleep-Wake Patterns Related with Depressive Severity in Patients with Epilepsy.Brain sciences · 2023Article
- Disrupted topological organization of functional brain networks in Alzheimer's disease patients with depressive symptoms.BMC psychiatry · 2022Article
- Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer's disease.Nature communications · 2022Article
- The Characteristics of Entorhinal Cortex Functional Connectivity in Alzheimer's Disease Patients with Depression.Current Alzheimer research · 2022Article
- Enhanced Association of Tau Pathology and Cognitive Impairment in Mild Cognitive Impairment Subjects with Behavior Symptoms.Journal of Alzheimer's disease : JAD · 2022Article
- Multiple system aging-related tau astrogliopathy with complex proteinopathy in an oligosymptomatic octogenarian.Neuropathology : official journal of the Japanese Society of Neuropathology · 2021Article
- Reduced uptake of [11C]-ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer's dementia.Brain and behavior · 2020Article
- An update on magnetic resonance imaging markers in AD.Therapeutic advances in neurological disorders · 2020Review
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Authors and funding
7 authors.
Funding
Abstract
purposeThe aim of the present study was to investigate the functional connectivity (FC) of Alzheimer's disease patients with depression (D-AD) based on an amygdalar seed using resting-state functional magnetic resonance imaging (rs-fMRI).
methodsTwenty-one non-depressed AD (nD-AD) patients and 21 D-AD patients underwent rs-fMRI. The Hamilton Depression Rating Scale and Neuropsychiatric Inventory were used to evaluate the severity of depression. The amygdala was used as the seed for FC analysis. The FC differences between the two groups were evaluated by two-sample t tests, and the correlation of FC changes with depressive severity was analyzed by Pearson correlational analysis.
resultsCompared with the nD-AD patients, D-AD patients had increased FC values between the amygdala and orbitofrontal cortex and decreased FC values among the amygdala, medial prefrontal cortex, and inferior frontal gyrus.
conclusionThese data suggest that abnormal amygdala-prefrontal FC may be an important characteristic of AD patients with depression.
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