Evidence map›Paper›PMID 30242221›Full record

ArticleTranslational psychiatry2018

Brain monoamine oxidase A in seasonal affective disorder and treatment with bright light therapy.

Marie Spies, Gregory M James, Chrysoula Vraka, Cécile Philippe, Marius Hienert, Gregor Gryglewski, Arkadiusz Komorowski, Alexander Kautzky, Leo Silberbauer, Verena Pichler and 13 more

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  11. Simultaneous radiomethylation of [Scientific reports · 2022
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  12. Seasonal Variation in the Brain μ-Opioid Receptor Availability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
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  13. "Shedding Light on Light": A Review on the Effects on Mental Health of Exposure to Optical Radiation.International journal of environmental research and public health · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 2 countries.

Marie SpiesDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Gregory M JamesDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Chrysoula VrakaDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Cécile PhilippeDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Marius HienertDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Gregor GryglewskiDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Arkadiusz KomorowskiDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-1674-4333
Alexander KautzkyDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Leo SilberbauerDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Verena PichlerDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Georg S KranzDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-3892-1804
Lukas NicsDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Theresa BalberDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Pia Baldinger-MelichDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Thomas VanicekDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Benjamin SpurnyDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Edda Winkler-PjrekDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Wolfgang WadsakDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-4479-8053
Markus MitterhauserDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Marcus HackerDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Siegfried KasperDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Rupert LanzenbergerDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. rupert.lanzenberger@meduniwien.ac.at.ORCID http://orcid.org/0000-0003-4641-9539
Dietmar WinklerDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATCenter For Biomarker Research In Medicine · ATLudwig Boltzmann Institute Applied Diagnostics · AT

Funding

Austrian Science Fund FWF KLI 504
6 · The paper itself

Abstract

Increased cerebral monoamine oxidase A (MAO-A) levels have been shown in non-seasonal depression using positron emission tomography (PET). Seasonal affective disorder (SAD) is a sub-form of major depressive disorder and is typically treated with bright light therapy (BLT). The serotonergic system is affected by season and light. Hence, this study aims to assess the relevance of brain MAO-A levels to the pathophysiology and treatment of SAD. Changes to cerebral MAO-A distribution (1) in SAD in comparison to healthy controls (HC), (2) after treatment with BLT and (3) between the seasons, were investigated in 24 patients with SAD and 27 HC using [

Indexed as

PhototherapyAdultBrainCarbon RadioisotopesFemaleHarmineHumansMaleMonoamine OxidasePositron-Emission TomographySeasonal Affective DisorderTreatment OutcomeCarbon RadioisotopesHarmineMonoamine Oxidasemonoamine oxidase A, human

Identifiers

PMID30242221
PMCPMC6155094
OpenAlexW2891017619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.