ArticleScientific reports2018
Mechanical loading, an important factor in the evaluation of ion release from bone augmentation materials.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
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Authors and funding
2 authors.
Funding
Abstract
The controlled release of therapeutic inorganic ions from biomaterials is an emerging area of international research. One of the foci for this research is the development of materials, which spatially and temporally modulate therapeutic release, via controlled degradation in the intended physiological environment. Crucially however, our understanding of the release kinetics for such systems remains limited, particularly with respect to the influence of physiological loading. Consequently, this study was designed to investigate the effect of dynamic mechanical loading on a composite material intended to stabilize, reinforce and strengthen vertebral bodies. The composite material contains a borate glass engineered to release strontium as a therapeutic inorganic ion at clinically relevant levels over extended time periods. It was observed that both cyclic (6 MPa 2 Hz) and static (4.3 MPa) compressive loading significantly increased the release of strontium ions in comparison to the static unloaded case. The observed alterations in ion release kinetics suggest that the mechanical loading of the implantation environment should be considered when evaluating the ion release kinetics.
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