Evidence map›Paper›PMID 30241715›Full record

ReviewInfectious disease clinics of North America2018

Understanding Biofilms and Novel Approaches to the Diagnosis, Prevention, and Treatment of Medical Device-Associated Infections.

Yu Mi Wi, Robin Patel

Abstract readReview
In one paragraph

Review in Infectious disease clinics of North America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Understanding bacterial biofilms: From definition to treatment strategies.Frontiers in cellular and infection microbiology · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yu Mi WiDivision of Infectious Diseases, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University, 158 palyong-ro, MasanHoiwon-gu, Changwon-si, Gyeongsangnam-do 51353, Korea.
Robin PatelDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Division of Infectious Diseases, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: robin.patel@mayo.edu.

Funding

The Electricidal Effect, a Novel Anti-Biofilm StrategyR01AI091594 · NIAID · MAYO CLINIC ROCHESTER · PI Haluk Beyenal, Robin Patel · 2011 to 2026
$5.5M
Molecular Detection of Biofilms on Hip and Knee ImplantsR01AR056647 · NIAMS · MAYO CLINIC ROCHESTER · PI PATEL, ROBIN · 2009 to 2020
$4.5M
Disappearance of rifampin resistance in MRSA foreign body osteomyelitisR21AI125870 · NIAID · MAYO CLINIC ROCHESTER · PI PATEL, ROBIN · 2016 to 2017
$437k
NIAID NIH HHS R01 AI091594NIAID NIH HHS R21 AI125870NIAMS NIH HHS R01 AR056647
6 · The paper itself

Abstract

Treatment of medical device-related infections is challenging and recurrence is common. The main reason for this is that microorganisms adhere to the surfaces of medical devices and enter into a biofilm state in which they display distinct growth rates, structural features, and protection from antimicrobial agents and host immune mechanisms compared with their planktonic counterparts. This article reviews how microorganisms form biofilms and the mechanisms of protection against antimicrobial agents and the host immune system provided by biofilms. Also discussed are innovative strategies for the diagnosis of biofilm-associated infection and novel approaches to treatment and prevention of medical device-associated infections.

Indexed as

BiofilmsBacterial InfectionsEquipment and SuppliesHumansBiofilmExtracellular polymeric substanceExtracellular polymeric substance targeting therapyMedical device-associated infectionPhysical–mechanical approachSurface-coating or eluting substrateTolerance

Identifiers

PMID30241715
PMCPMC6215726

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.