Evidence map›Paper›PMID 30241697›Full record

ArticleAtherosclerosis2018

Associations of cardiovascular fat radiodensity and vascular calcification in midlife women: The SWAN cardiovascular fat ancillary study.

Carrie Hanley, Kelly J Shields, Karen A Matthews, Maria M Brooks, Imke Janssen, Matthew J Budoff, Akira Sekikawa, Suresh Mulukutla, Samar R El Khoudary

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Carrie HanleyUniversity of Pittsburgh Graduate School of Public Health, Department of Epidemiology, 130 De Soto Street, Pittsburgh, PA, 15261, USA.
Kelly J ShieldsLupus Center of Excellence, Autoimmunity Institute, Department of Medicine, Allegheny Health Network, 320 E. North Avenue, Pittsburgh, PA, 15212, USA.
Karen A MatthewsUniversity of Pittsburgh Graduate School of Public Health, Department of Epidemiology, 130 De Soto Street, Pittsburgh, PA, 15261, USA; University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.
Maria M BrooksUniversity of Pittsburgh Graduate School of Public Health, Department of Epidemiology, 130 De Soto Street, Pittsburgh, PA, 15261, USA.
Imke JanssenRush University Medical Center, Department of Preventive Medicine, 1700 W. Van Buren Street, Chicago, IL, 60612, USA.
Matthew J BudoffLos Angeles Biomedical Research Institute, Division of Cardiology, 1124 W. Carson Street, Torrance, CA, 90502, USA.
Akira SekikawaUniversity of Pittsburgh Graduate School of Public Health, Department of Epidemiology, 130 De Soto Street, Pittsburgh, PA, 15261, USA.
Suresh MulukutlaUniversity of Pittsburgh School of Medicine, Department of Medicine, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.
Samar R El KhoudaryUniversity of Pittsburgh Graduate School of Public Health, Department of Epidemiology, 130 De Soto Street, Pittsburgh, PA, 15261, USA; University of Pittsburgh School of Pharmacy, Department of Pharmacy and Therapeutics, 3501 Terrace Street, Pittsburgh, PA, 15213, USA. Electronic address: elkhoudarys@edc.pitt.edu.
University of Pittsburgh · USAllegheny Health Network · USRush University Medical Center · USThe Lundquist Institute · US

Funding

WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
PREVALENCE &PROGRESSION OF SUBCLINICAL ATHEROSCLEROSISR01HL065591 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TYRRELL, KIM SUTTON · 2000 to 2003
$2.6M
PREVALENCE &PROGRESSION OF SUBCLINICAL ATHEROSCLEROSISR01HL065581 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI POWELL, LYNDA H · 2000 to 2003
$1.9M
NHLBI NIH HHS R01 HL065581NHLBI NIH HHS R01 HL065591NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NINR NIH HHS U01 NR004061
6 · The paper itself

Abstract

BACKGROUND AND

aimsFat radiodensity, measured via CT Hounsfield units (HU), is a potential marker of fat quality. We sought to determine the cross-sectional associations of total heart fat (TAT) and aortic perivascular fat (PVAT) radiodensity with cardiovascular risk factors, coronary artery calcification (CAC), and aortic calcification (AC) in midlife women.

methodsFat radiodensity, CAC, and AC were quantified using CT scans. A total of 528 women (mean age: 50.9 ± 2.9 years; 37% Black) were included in analyses.

resultsWomen in the lowest TAT radiodensity tertile were more likely to have adverse cardiovascular risk factors. Independent of cardiovascular risk factors, women in the middle and high TAT radiodensity tertiles were less likely to have CAC (OR (95% CI): 0.32 (0.18, 0.59); 0.43 (0.24, 0.78), respectively) compared with women in the lowest TAT radiodensity tertile. Although adjusting for BMI attenuated the overall association, women in the middle TAT radiodensity tertile remained at significantly lower odds of CAC when compared to the low radiodensity tertile, 0.47 (0.24, 0.93), p=0.03. No significant associations were found for PVAT radiodensity and calcification measures in multivariable analysis.

conclusionsLower TAT radiodensity was associated with a less favorable cardiometabolic profile. Women with mid-range TAT radiodensity values had a lower odds of CAC presence, independent of CVD risk factors and BMI. More research is necessary to understand radiodensity as a surrogate marker of fat quality in midlife women.

Indexed as

Computed Tomography AngiographyWomen's HealthAdipose TissueAdiposityAge FactorsAortic DiseasesAortographyCoronary AngiographyCoronary Artery DiseaseCross-Sectional StudiesFemaleHumansMiddle AgedPredictive Value of TestsPrognosisProspective StudiesCardiovascularFat radiodensityMidlife womenVascular calcification

Identifiers

PMID30241697
PMCPMC6295258
OpenAlexW2891377624

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.