ArticleJournal of autoimmunity2019
T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation.
Abstract read
In one paragraph
Article in Journal of autoimmunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Age-Specific Imbalance of Circulating Tfh Cell Subsets and Its Association With Gout-Targeted Kidney Impairment.Frontiers in immunology · 2020Trial
- Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease.Journal of periodontology · 2026Article
- Intestinal transcriptomic analysis and prediction of biomarkers associated with mucosal healing following vedolizumab treatment in ulcerative colitis using machine learning.BMC gastroenterology · 2026Article
- Association of miR-10a expression and its rs3809783 polymorphism with postoperative incisional pain via Bcl-6/Tfh targeting in patients undergoing laparoscopic cholecystectomy.American journal of clinical and experimental immunology · 2026Article
- The interaction between dendritic cells and T follicular helper cells drives inflammatory bowel disease: a review.Frontiers in immunology · 2026Review
- Reconstitution of T cell-mediated immunity by umbilical cord-derived mesenchymal stem cells in ulcerative colitis.Clinical and translational medicine · 2025Article
- Identification of MEG3 and MAPK3 as potential therapeutic targets for osteoarthritis through multiomics integration and machine learning.Scientific reports · 2025Article
- Immune imbalance and autoimmune mechanisms in plasma cell mastitis: current perspectives.Frontiers in cell and developmental biology · 2025Review
- Multi-Omics Profiling Unveils the Complexity and Dynamics of Immune Infiltrates in Intrahepatic Cholangiocarcinoma.Biology · 2024Article
- The multiple roles of interferon regulatory factor family in health and disease.Signal transduction and targeted therapy · 2024Review
- Unravelling the Oral-Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective.Journal of Crohn's & colitis · 2024Review
- Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development.Nature immunology · 2024Article
- Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans.Nature immunology · 2024Article
- Targeted delivery of Fc-fused PD-L1 for effective management of acute and chronic colitis.Nature communications · 2024Article
- Immune cells and their related genes provide a new perspective on the common pathogenesis of ankylosing spondylitis and inflammatory bowel diseases.Frontiers in immunology · 2023Article
- Altered Phenotypes of Colonic and Peripheral Blood Follicular Helper and Follicular Cytotoxic T Cells in Mice with DSS-Induced Colitis.Journal of inflammation research · 2023Article
- MicroRNA expression profile of chicken cecum in different stages during Histomonas meleagridis infection.BMC veterinary research · 2022Article
- The Role of the Lymphatic System in the Pathogenesis and Treatment of Inflammatory Bowel Disease.International journal of molecular sciences · 2022Review
- Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire.The Journal of experimental medicine · 2021Article
- The Role of T Follicular Helper Cells and Interleukin-21 in the Pathogenesis of Inflammatory Bowel Disease.Gastroenterology research and practice · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 6 institutions in 1 country.
Ruihua ZhangDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Chen-Feng QiLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Yuan HuDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Yanhong ShanDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Yuan-Pang HsiehDepartment of Biological Sciences, College of Science, Virginia Tech, USA.
Feihong XuDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Geming LuDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jun DaiDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Monica GuptaPrograms in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Miao CuiDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Liang PengDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jianjun YangDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Qingjie XueDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Ray Chen-LiangDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kang ChenDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.
Yeyunfei ZhangDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Wai-Ping Fung-LeungJanssen Research & Development, LLC., CA 92121, USA.
J Rodrigo MoraJanssen R&D, Spring House, PA 19477, USA.
Liwu LiDepartment of Biological Sciences, College of Science, Virginia Tech, USA.
Herbert C MorseLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Keiko OzatoPrograms in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Peter S HeegerDepartment of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: peter.heeger@mssm.edu.
Huabao XiongDepartment of Medicine, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: huabao.xiong@mssm.edu.
Icahn School of Medicine at Mount Sinai · USNational Institutes of Health · USJanssen (United States) · USVirginia Tech · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USWayne State University · US
Funding
Chromatin and epigenetic memory ZIAHD008815 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI OZATO, KEIKO · 2009 to 2025
$16.2MGene Regulation In The Immune SystemZIAHD001310 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI OZATO, KEIKO · 2009 to 2025
$15.0MComplement & T Cell Medicated Allograft RejectionR01AI071185 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT · 2007 to 2016
$4.3MCell Death Pathways and Heart Transplant RejectionR01AI132405 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT, TING, ADRIAN T · 2017 to 2021
$2.8MT cell-derived iNOS switches off TH17 cell differentiation in inflammationR01AI104688 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI XIONG, HUABAO · 2013 to 2016
$1.7MMechanism of Humoral Immune Defects in Autoimmune Polyglandular Syndrome Type 1R21AI122256 · NIAID · WAYNE STATE UNIVERSITY · PI CHEN, KANG · 2016 to 2017
$419kNIAID NIH HHS R01 AI071185NIAID NIH HHS R01 AI104688NIAID NIH HHS R01 AI132405
Abstract
The follicular helper T cell (T
Indexed as
Adoptive TransferAnimalsB-LymphocytesCells, CulturedColitisColonCrohn DiseaseDisease Models, AnimalGerminal CenterHumansInterferon Regulatory Factor-8Interferon Regulatory FactorsLymphocyte ActivationMiceMice, KnockoutParacrine CommunicationBcl6 protein, mouseInterferon Regulatory Factor-8Interferon Regulatory FactorsProto-Oncogene Proteins c-bcl-6ColitisIRF4IRF8TFH
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.