ArticleCell2018
Identification of the Human Skeletal Stem Cell.
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Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 368 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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368citing papers in PubMed, 1 pooled it
39.2field-weighted citation impact, top 1% of its field
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Who cites it
368 citing papers in PubMed, 1 synthesis or guideline pooled it, 584 citations in OpenAlex.
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- Nasal septum-derived chondroprogenitor cells control mandibular condylar resorption consequent to orthognathic surgery: a clinical trial.Stem cells translational medicine · 2024Trial
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- Decoding Skeletal Biology Through Transcriptomics: Insights from Bulk, Single-Cell, Spatial, and Multi-Omics Approaches.International journal of molecular sciences · 2026Review
- Skeletal stem and progenitor cell niche organization, regulation and repair.Reviews in endocrine & metabolic disorders · 2026Review
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- Chondrocytes in fracture healing: A review of chondrocyte journey.Chinese medical journal · 2026Review
- An ITGA11 expressing subpopulation as predictor for the donor-specific osteogenic capacity of stromal cells.Bone research · 2026Article
- Developing WNT-derived bone anabolic peptides for skeletal aging and fracture by reconstructing thumb and index domains of WNT7B.Nature biomedical engineering · 2026Article
- Lineage topology, replication kinetics and cell cycle synchronization reveal regulated growth dynamics in human bone marrow stromal cell colonies.Scientific reports · 2026Article
- CK2.1 Activates Chondrogenesis by Regulation of the p38 Mitogen-Activated Protein Kinase Pathway.Kinases and phosphatases · 2026Article
- Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy.Advanced healthcare materials · 2026Review
- Type E endothelial cells orchestrate embryonic skeletogenesis via chondrogenic priming of skeletal progenitors.Journal of orthopaedic translation · 2026Article
308 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
36 authors at 4 institutions in 2 countries.
Charles K F ChanDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA. Electronic address: chazchan@stanford.edu.
Gunsagar S GulatiDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Rahul SinhaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Justin Vincent TompkinsDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Michael LopezDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Ava C CarterCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
Ryan C RansomDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Andreas ReinischInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Taylor WeardaDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Matthew MurphyDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Rachel E BrewerDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Lauren S KoepkeDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Owen MarecicDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Anoop ManjunathDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Eun Young SeoDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Tripp LeavittDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Wan-Jin LuInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Allison NguyenInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Stephanie D ConleyInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Ankit SalhotraDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Thomas H AmbrosiDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Mimi R BorrelliDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Taylor SiebelInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Karen ChanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Katharina SchallmoserDepartment of Blood Group Serology and Transfusion Medicine, Medical University of Graz, 8036 Graz, Austria.
Jun SeitaMedical Sciences Innovation Hub Program, RIKEN, Tokyo 103-0027, Japan.
Debashis SahooDepartments of Pediatrics and Computer Science and Engineering, University of California San Diego, San Diego, CA 92093, USA.
Henry GoodnoughDepartment of Orthopedic Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Julius BishopDepartment of Orthopedic Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Michael GardnerDepartment of Orthopedic Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Ravindra MajetiDepartment of Medicine, Division of Hematology, Stanford Medicine, Stanford, CA 94305, USA.
Derrick C WanDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Stuart GoodmanDepartment of Orthopedic Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
Michael T LongakerDepartment of Surgery, Stanford Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA. Electronic address: longaker@stanford.edu.
Stanford Medicine · USStanford University · USMedical University of Graz · ATUniversity of California, San Diego · US
Funding
Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI WONG, WING H. · 2014 to 2018
$15.2MCenter for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)U24DE026914 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAI, YANG, CHEN, YONG · 2017 to 2019
$12.0MInduced pluripotent stem cells in the understanding and treatment of heart diseaseU01HL099776 · NHLBI · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, WU, JOSEPH C. · 2009 to 2015
$8.2MInterrogation of individual cells to identify progenitors and their nichesU01HL099999 · NHLBI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2009 to 2015
$7.8MHSC Diversity: Regulation by Clonal Selection vs Epigenetic InductionR01CA086065 · NCI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2000 to 2017
$6.9MHOMING RECEPTOR DETERMINANTS ON HSCR01HL058770 · NHLBI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 1998 to 2013
$3.9MWear Particle Disease and NF-kappa B SignalingR01AR063717 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2012 to 2021
$3.5MChemokine Directed Cell Trafficking during Continuous Infusion of Wear ParticlesR01AR055650 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2007 to 2016
$3.3MOsteogenic Enrichment of Adipose Derived Stromal CellsR01DE021683 · NIDCR · STANFORD UNIVERSITY · PI GURTNER, GEOFFREY C, LONGAKER, MICHAEL T · 2012 to 2016
$2.0MIdentifying the human skeletal stem cell.R01DE027323 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2018 to 2022
$1.9MCellular and Mechanical Mechanisms Regulating Mandibular Distraction OsteogenesisR01DE026730 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2017 to 2021
$1.9MCellular and molecular analyses of hematopoietic stem cell [HSC] interactions with bone marrow niches to improve HSC engraftment for transplantation and tolerance inductionR01DK115600 · NIDDK · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2018 to 2021
$1.5MHoward Hughes Medical InstituteNCI NIH HHS R01 CA086065NHGRI NIH HHS P50 HG007735NHLBI NIH HHS R01 HL058770NHLBI NIH HHS U01 HL099776NHLBI NIH HHS U01 HL099999NIAMS NIH HHS R01 AR055650NIAMS NIH HHS R01 AR063717NIA NIH HHS K99 AG049958NIA NIH HHS R00 AG049958NIDCR NIH HHS R01 DE021683NIDCR NIH HHS R01 DE026730NIDCR NIH HHS R01 DE027323NIDCR NIH HHS R21 DE019274NIDCR NIH HHS R21 DE024230NIDCR NIH HHS R56 DE025597NIDCR NIH HHS U24 DE026914NIDDK NIH HHS R01 DK115600
Abstract
Stem cell regulation and hierarchical organization of human skeletal progenitors remain largely unexplored. Here, we report the isolation of a self-renewing and multipotent human skeletal stem cell (hSSC) that generates progenitors of bone, cartilage, and stroma, but not fat. Self-renewing and multipotent hSSCs are present in fetal and adult bones and can also be derived from BMP2-treated human adipose stroma (B-HAS) and induced pluripotent stem cells (iPSCs). Gene expression analysis of individual hSSCs reveals overall similarity between hSSCs obtained from different sources and partially explains skewed differentiation toward cartilage in fetal and iPSC-derived hSSCs. hSSCs undergo local expansion in response to acute skeletal injury. In addition, hSSC-derived stroma can maintain human hematopoietic stem cells (hHSCs) in serum-free culture conditions. Finally, we combine gene expression and epigenetic data of mouse skeletal stem cells (mSSCs) and hSSCs to identify evolutionarily conserved and divergent pathways driving SSC-mediated skeletogenesis. VIDEO ABSTRACT.
Indexed as
AnimalsBone and BonesBone DevelopmentCartilageCell DifferentiationHematopoietic Stem CellsHumansInduced Pluripotent Stem CellsMesenchymal Stem CellsMiceMice, Inbred C57BLSignal TransductionSingle-Cell AnalysisStem CellsStromal CellsTranscriptomeand stromal progenitorATAC-sequencingbonebone fracture repairbone marrow nichecartilageHSChuman skeletal stem cellsingle cell RNA-sequencing
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