Evidence map›Paper›PMID 30241536›Full record

SynthesisNutrition journal2018

Association between whole grain intake and breast cancer risk: a systematic review and meta-analysis of observational studies.

Yunjun Xiao, Yuebin Ke, Shuang Wu, Suli Huang, Siguo Li, Ziquan Lv, Eng-Kiong Yeoh, Xiangqian Lao, Samuel Wong, Jean Hee Kim and 3 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrition journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  5. Trial
  6. Article
  7. Foods (Basel, Switzerland) · 2025
    Article
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  20. General Health Benefits and Pharmacological Activities ofMolecules (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Yunjun XiaoShenzhen Key Laboratory of Molecular Epidemiology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
Yuebin KeShenzhen Key Laboratory of Molecular Epidemiology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
Shuang WuShenzhen Key Laboratory of Molecular Epidemiology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
Suli HuangShenzhen Key Laboratory of Molecular Epidemiology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
Siguo LiShenzhen Key Laboratory of Molecular Epidemiology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
Ziquan LvShenzhen Key Laboratory of Molecular Epidemiology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
Eng-Kiong YeohSchool of Public Health and Primary Care, Faculty of Medicine, School of Public Health, Prince of Wales Hospital, The Chinese University of Hong Kong, Room 508, Shatin, New Territories, Hong Kong, China.
Xiangqian LaoSchool of Public Health and Primary Care, Faculty of Medicine, School of Public Health, Prince of Wales Hospital, The Chinese University of Hong Kong, Room 508, Shatin, New Territories, Hong Kong, China.
Samuel WongSchool of Public Health and Primary Care, Faculty of Medicine, School of Public Health, Prince of Wales Hospital, The Chinese University of Hong Kong, Room 508, Shatin, New Territories, Hong Kong, China.
Jean Hee KimSchool of Public Health and Primary Care, Faculty of Medicine, School of Public Health, Prince of Wales Hospital, The Chinese University of Hong Kong, Room 508, Shatin, New Territories, Hong Kong, China.
Graham A ColditzAlvin J. Siteman Cancer Center and Department of Surgery, Washington University School of Medicine, St. Louis, USA.
Rulla M TamimiChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA. rulla.tamimi@channing.harvard.edu.
Xuefen SuSchool of Public Health and Primary Care, Faculty of Medicine, School of Public Health, Prince of Wales Hospital, The Chinese University of Hong Kong, Room 508, Shatin, New Territories, Hong Kong, China. xuefensu@cuhk.edu.hk.
Shenzhen Center for Disease Control and Prevention · CNChinese University of Hong Kong · CNAlvin J. Siteman Cancer CenterBrigham and Women's Hospital · USPrince of Wales Hospital · CN

Funding

Hong Kong Research Grants Council General Research Fund 2140904National Natural Science Foundation of China 81402672
6 · The paper itself

Abstract

backgroundEpidemiological studies have found that high whole grain intake may be associated with a reduced risk of breast cancer. However, the evidence has not been consistent. We conducted a meta-analysis to quantitatively assess the association between whole grain intake and breast cancer risk.

methodsRelevant observational studies were identified by searching PubMed, Embase, Cochrane library databases, and Google Scholar through April 2017. Summary relative risk (RR) estimates were calculated using random-effects meta-analysis.

resultsA total of 11 studies, including 4 cohort and 7 case-control studies and involving 131,151 participants and 11,589 breast cancer cases, were included in the current meta-analysis. The pooled RR of breast cancer for those with high versus low whole grain intake was 0.84 (95% confidence interval [CI]: 0.74 to 0.96, p = 0.009; I

conclusionsResults of the current meta-analysis suggest that high intake of whole grains might be inversely associated with a reduced risk of breast cancer, and the inverse association was only observed in case-control but not cohort studies. More large-scale cohort studies are needed to confirm the inverse association observed.

Indexed as

Whole GrainsAdultAgedBreast NeoplasmsDietFemaleHumansMiddle AgedObservational Studies as TopicRisk FactorsBreast cancerMeta-analysisObservational studiesWhole grain

Identifiers

PMID30241536
PMCPMC6201708
OpenAlexW2890590150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.