Evidence map›Paper›PMID 30241374›Full record

ArticleMolecules (Basel, Switzerland)2018

Design, Synthesis and Docking Studies of Novel Macrocyclic Pentapeptides as Anticancer Multi-Targeted Kinase Inhibitors.

Abd El-Galil E Amr, Mohamed H Abo-Ghalia, Gaber O Moustafa, Mohamed A Al-Omar, Eman S Nossier, Elsayed A Elsayed

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. NDrug design, development and therapy · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Journal of enzyme inhibition and medicinal chemistry · 2019
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Frontiers in chemistry · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abd El-Galil E AmrPharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. aeamr1963@yahoo.com.ORCID 0000-0002-1338-706X
Mohamed H Abo-GhaliaDepartment of Peptide Chemistry, National Research Centre, 12622 Dokki, Giza, Egypt. mhaboghalia@yahoo.com.ORCID 0000-0002-6213-5897
Gaber O MoustafaDepartment of Peptide Chemistry, National Research Centre, 12622 Dokki, Giza, Egypt. gosman79@gmail.com.ORCID 0000-0002-2489-8228
Mohamed A Al-OmarPharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. malomar1@ksu.edu.sa.ORCID 0000-0002-9866-343X
Eman S NossierDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, 11754 Cairo, Egypt. dr.emannossier@gmail.com.
Elsayed A ElsayedBioproducts Research Department, Zoology Department, Faculty of Science, King Saud University, Riyadh 11451, Saudi Arabia. eaelsayed@ksu.edu.sa.ORCID 0000-0002-4774-4600

Funding

King Saud University Deanship of Scientific Research, king Saud University for funding through Vice Deanship of Scientific Research Chairs
6 · The paper itself

Abstract

A series of macrocyclic pyrido-pentapeptide candidates

Indexed as

Antineoplastic AgentsCell ProliferationCyclin-Dependent Kinase 2Drug Screening Assays, AntitumorGene Expression Regulation, NeoplasticHep G2 CellsHumansMacrocyclic CompoundsMCF-7 CellsMolecular Docking SimulationMolecular StructureNeoplasmsPeptidesProtein Kinase InhibitorsReceptor, Platelet-Derived Growth Factor betaStructure-Activity RelationshipAntineoplastic AgentsCyclin-Dependent Kinase 2Macrocyclic CompoundsPeptidesProtein Kinase InhibitorsReceptor, Platelet-Derived Growth Factor betaVascular Endothelial Growth Factor Receptor-2in vitro anticancer activitymacrocyclic pentapeptidesmolecular modeling studiesmultitarget

Identifiers

PMID30241374
PMCPMC6222410

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.