Evidence map›Paper›PMID 30241340›Full record

ArticleInternational journal of molecular sciences2018

Novel Methylselenoesters Induce Programed Cell Death via Entosis in Pancreatic Cancer Cells.

Prajakta Khalkar, Nuria Díaz-Argelich, Juan Antonio Palop, Carmen Sanmartín, Aristi P Fernandes

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Entosis in Health and Disease.Advances in experimental medicine and biology · 2025
    Review
  3. Sphingolipid metabolism and regulated cell death in malignant melanoma.Apoptosis : an international journal on programmed cell death · 2024
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
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  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. THE MAIN CYTOTOXIC EFFECTS OF METHYLSELENINIC ACID ON VARIOUS CANCER CELLS.International journal of molecular sciences · 2021
    Review
  18. Review
  19. Selenium Compounds as Novel Potential Anticancer Agents.International journal of molecular sciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Prajakta KhalkarDivision of Biochemistry, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, SE-171 77 Stockholm, Sweden. prajakta.khalkar@ki.se.ORCID 0000-0002-9384-2922
Nuria Díaz-ArgelichDivision of Biochemistry, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, SE-171 77 Stockholm, Sweden. ndiaz@alumni.unav.es.ORCID 0000-0001-7713-1664
Juan Antonio PalopDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain. japcubillo@gmail.com.
Carmen SanmartínDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain. sanmartin@unav.es.
Aristi P FernandesDivision of Biochemistry, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, SE-171 77 Stockholm, Sweden. Aristi.Fernandes@ki.se.
Karolinska Institutet · SENavarre Institute of Health Research · ES

Funding

Cancerfonden CAN 2016/606
6 · The paper itself

Abstract

Redox active selenium (Se) compounds have gained substantial attention in the last decade as potential cancer therapeutic agents. Several Se compounds have shown high selectivity and sensitivity against malignant cells. The cytotoxic effects are exerted by their biologically active metabolites, with methylselenol (CH₃SeH) being one of the key executors. In search of novel CH₃SeH precursors, we previously synthesized a series of methylselenoesters that were active (GI

Indexed as

Antineoplastic Agentscdc42 GTP-Binding ProteinCell Line, TumorDown-RegulationEntosisHomeostasisHumansMethanolOrganoselenium CompoundsOxidation-ReductionPancreatic NeoplasmsSelenium CompoundsAntineoplastic Agentscdc42 GTP-Binding ProteinCDC42 protein, humanmethaneselenolMethanolmethylselenic acidOrganoselenium CompoundsSelenium Compoundsanticancer agententosismethylselenoestersselenium

Identifiers

PMID30241340
PMCPMC6213452
OpenAlexW2892095461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.