ArticleMolecules (Basel, Switzerland)2018
Enhancement of Cell Adhesion, Cell Growth, Wound Healing, and Oxidative Protection by Gelatins Extracted from Extrusion-Pretreated Tilapia (
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Valorization of aquaculture side streams from sea bream and sea bass by enzymatic hydrolysis and fractionation: chemical and biological insights.Frontiers in nutrition · 2025Article
- Effect of Spirulina and Fish Processing By-Products Extracts on Citrinin-Induced Cytotoxicity in SH-SY5Y Cells.Foods (Basel, Switzerland) · 2024Article
- Gelatin nanofibers: Recent insights in synthesis, bio-medical applications and limitations.Heliyon · 2023Review
- Effect of Oversulfation on the Composition, Structure, and In Vitro Anti-Lung Cancer Activity of Fucoidans Extracted fromMarine drugs · 2021Article
- Cosmetic, Biomedical and Pharmaceutical Applications of Fish Gelatin/Hydrolysates.Marine drugs · 2021Review
- Effect of hydrolyzed collagen from defatted Asian sea bass (Journal of food science and technology · 2021Article
- Degradation ofMarine drugs · 2020Article
- Gelatin-Based Hydrogels for the Controlled Release of 5,6-Dihydroxyindole-2-Carboxylic Acid, a Melanin-Related Metabolite with Potent Antioxidant Activity.Antioxidants (Basel, Switzerland) · 2020Article
- Fish Scale Valorization by Hydrothermal Pretreatment Followed by Enzymatic Hydrolysis for Gelatin Hydrolysate Production.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
6 authors.
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Abstract
Gelatin has been broadly utilized in the food, pharmaceutical, photographic, cosmetic and packaging industries, and there is also huge potential for novel applications of gelatin in the fields of biotechnology and biomedicine. In the present study, we extracted gelatin from fish processing waste, i.e., scale of tilapia, by a combined method of extrusion-pretreatment and hot water extraction. The extrusion-pretreatment process increases the extraction yield of gelatin. Three gelatins (FS2: preconditioning with double-distilled water (ddH₂O) before extrusion; FS12: preconditioning with citric acid solution before extrusion; FS14: preconditioning with acetic acid solution before extrusion) were obtained and all of them enhanced cell adhesion, cell growth, and wound healing in HaCaT cells and protected HaCaT cells from H₂O₂-induced cellular damage. Among FS2, FS12, and FS14, FS12 exhibited the most pronounced enhancement of cell adhesion, cell growth, and wound healing in HaCaT cells, and thus it may have potential as an effective natural raw material in cell therapies for cutaneous wounds and for reducing H₂O₂-induced oxidative damage of cells. In additional experiments, it was found that phosphorylations of Akt and mTOR are involved in the signaling pathway activated by FS2, FS12, and FS14 in HaCaT cells.
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