Evidence map›Paper›PMID 30241276›Full record

Trial reportJournal of global oncology2018

Stage III Non-Small-Cell Lung Cancer Treated With Concurrent Chemoradiation Followed or Not by Consolidation Chemotherapy: A Survival Analysis From a Brazilian Multicentric Cohort.

Vladmir C Cordeiro de Lima, Clarissa S Baldotto, Carlos H Barrios, Eldsamira M Sobrinho, Mauro Zukin, Clarissa Mathias, Facundo Zaffaroni, Rodrigo C Nery, Gabriel Madeira, Alex V Amadio and 4 more

Open access · goldAbstract readClinical Trial, Phase IIIMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of global oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Vladmir C Cordeiro de LimaVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Clarissa S BaldottoVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Carlos H BarriosVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Eldsamira M SobrinhoVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Mauro ZukinVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Clarissa MathiasVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Facundo ZaffaroniVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Rodrigo C NeryVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Gabriel MadeiraVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Alex V AmadioVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Juliano C CoelhoVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Guilherme GeibVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Maria Fernanda SimõesVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Gilberto CastroVladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.
Instituto Nacional do Câncer · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOf newly diagnosed patients with non-small-cell lung cancer (NSCLC), stage III accounts for 30%. Most patients are treated with concurrent chemoradiation therapy, but the addition of consolidation chemotherapy (CC) is debatable. We examined the effect of CC in Brazilian patients with stage III NSCLC treated in routine clinical practice.

methodsWe retrospectively collected data for patients from five different Brazilian cancer institutions who had stage III NSCLC and who were treated with chemoradiation therapy followed or not by CC. Eligible patients were age 18 years or older and must have been treated with cisplatin-carboplatin plus etoposide, paclitaxel, or vinorelbine, concurrently with thoracic radiation therapy (RT). Patients treated with surgery or neoadjuvant chemotherapy were excluded. The primary end point was overall survival (OS). Associations between CC and clinical variables and demographics were evaluated by using Pearson's χ

resultsWe collected data from 165 patients. Median age was 60 years. Most patients were male (69.1%), white (77.9%), current or former smokers (93.3%), and had stage IIIB disease (52.7%). Adenocarcinoma was the most common histology (47.9%). Weight loss of more than 5% was observed in 39.1% and Eastern Cooperative Oncology Group performance status of 2 was observed in 14.6%. The only variable associated with CC was T stage ( P = .022). We observed no statistically significant difference in OS between patients treated or not with CC ( P = .128). A total delivered RT dose ≥ 61 Gy was the only variable independently associated with improved survival ( P = .012).

conclusionBrazilian patients with locally advanced NSCLC who were treated with standard treatment achieved OS similar to that reported in randomized trials. CC did not improve OS in patients with stage III NSCLC after concurrent chemoradiation therapy. An RT dose of less than 61 Gy had a negative effect on OS.

Indexed as

ChemoradiotherapyAgedAntineoplastic Combined Chemotherapy ProtocolsBrazilCarboplatinCarcinoma, Non-Small-Cell LungCisplatinCombined Modality TherapyConsolidation ChemotherapyFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPaclitaxelProgression-Free SurvivalCarboplatinCisplatinPaclitaxel

Identifiers

PMID30241276
PMCPMC6223524
OpenAlexW2799951561

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.