ArticleNucleic acids research1986
Gene organization of the small subunit of human calcium-activated neutral protease.
Article in Nucleic acids research, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Calpain chronicle--an enzyme family under multidisciplinary characterization.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2011Review
- A new SNP in the 3'UTR region of the bovine calpain small subunit (CAPNS1) gene.Molecular biology reports · 2010Article
- The effect of multiple binding modes on empirical modeling of ligand docking to proteins.Protein science : a publication of the Protein Society · 1999Article
- Auracyanin A from the thermophilic green gliding photosynthetic bacterium Chloroflexus aurantiacus represents an unusual class of small blue copper proteins.Protein science : a publication of the Protein Society · 1999Article
- Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification.Biophysical journal · 1997Article
- The tra-3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family.The EMBO journal · 1996Article
- Evolution of EF-hand calcium-modulated proteins. III. Exon sequences confirm most dendrograms based on protein sequences: calmodulin dendrograms show significant lack of parallelism.Journal of molecular evolution · 1993Article
- Evolution of EF-hand calcium-modulated proteins. IV. Exon shuffling did not determine the domain compositions of EF-hand proteins.Journal of molecular evolution · 1993Article
- Gene expression of calpains and their specific endogenous inhibitor, calpastatin, in skeletal muscle of fed and fasted rabbits.The Biochemical journal · 1992Article
- Characterization and genetic mapping of a short, highly repeated, interspersed DNA sequence from rice (Oryza sativa L.).Molecular & general genetics : MGG · 1992Article
- Investigation of the role of calpain as a stimulus-response mediator in human platelets using new synthetic inhibitors.The Biochemical journal · 1991Article
- Evolution of EF-hand calcium-modulated proteins. I. Relationships based on amino acid sequences.Journal of molecular evolution · 1990Article
- Do exons code for structural or functional units in proteins?Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Evolution of the EF-hand calcium-binding protein family: evidence for exon shuffling and intron insertion.Journal of molecular evolution · 1988Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gene for the small subunit of human calcium-activated neutral protease was isolated and sequenced. It is 11 kb long and comprises 11 exons. No TATA or CAT box was found upstream of the possible transcription initiation sites, but there are three so-called G-C box sequences and one G-C box-like sequence, which are usually found in "house-keeping" genes. The first exon (exon 1) contains only the 5'-noncoding sequence and exon 2 encodes the Gly-rich hydrophobic domain. Each of the four calcium-binding loop regions is encoded by one exon (exons 7-10). The intron breakpoints in the C-terminal calcium-binding domain (exons 4-11) completely coincide with those of the chicken large subunit gene. These findings suggest that the small and large subunits have evolved from the same ancestral calcium-binding protein and have retained the original gene organization.
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