Evidence map›Paper›PMID 30240938›Full record

ArticleOsteoarthritis and cartilage2019

The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis.

J D Guss, S N Ziemian, M Luna, T N Sandoval, D T Holyoak, G G Guisado, S Roubert, R L Callahan, I L Brito, M C H van der Meulen and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.

  1. Pooled it
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  8. Observational
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  10. Article
  11. Osteoarthritis as a systemic disease.Nature reviews. Rheumatology · 2026
    Review
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

J D GussSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
S N ZiemianSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
M LunaSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
T N SandovalSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA.
D T HolyoakSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
G G GuisadoSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA.
S RoubertSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA.
R L CallahanMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
I L BritoMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
M C H van der MeulenSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA; Hospital for Special Surgery, New York, NY, USA.
S R GoldringHospital for Special Surgery, New York, NY, USA.
C J HernandezSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA; Hospital for Special Surgery, New York, NY, USA. Electronic address: cjh275@cornell.edu.
Cornell University · USHospital for Special Surgery · US

Funding

Acquisition of a Nano Computed Tomography Instrument for shared Cornell Imaging fS10OD012287 · OD · CORNELL UNIVERSITY · PI HERNANDEZ, CHRISTOPHER JOHN · 2013 to 2013
$755k
Separating Systemic Inflammation From Obesity in Load-Induced OsteoarthritisR21AR068061 · NIAMS · CORNELL UNIVERSITY · PI HERNANDEZ, CHRISTOPHER JOHN · 2015 to 2016
$371k
Associations between gut microbiota, flagellin production and bone microstructureF33AR065348 · NIAMS · CORNELL UNIVERSITY · PI HERNANDEZ, CHRISTOPHER JOHN · 2013 to 2013
$51k
NIAMS NIH HHS F33 AR065348NIAMS NIH HHS R21 AR068061NIH HHS S10 OD012287
6 · The paper itself

Abstract

objectiveMetabolic syndrome is characterized by obesity, hyperglycemia, hypertension, insulin resistance, and dyslipidemia. Metabolic syndrome is associated with osteoarthritis (OA), but it is unclear if the association is attributable to increased mechanical loading on joints caused by obesity or other aspects of metabolic syndrome. Here we examined the effects of altered metabolism, obesity, and the gut microbiome on load-induced OA.

designCartilage damage was induced through cyclic compressive loading in four groups of adult male mice: Toll-like receptor-5 deficient (TLR5KO) mice that develop metabolic syndrome due to alterations in the gut microbiome, TLR5KO mice submitted to chronic antibiotics to prevent metabolic syndrome (TLR5KOΔMicrobiota), C57BL/6J mice fed a high fat diet to cause obesity (HFD), and untreated C57BL/6J mice (WT). Loading was applied for 2 weeks (n = 10-11/group) or 6 weeks (n = 10-11/group).

resultsAfter 2 weeks of loading, cartilage damage (OARSI score) was not different among groups. After 6 weeks of loading, HFD mice had increased load-induced cartilage damage, while TLR5KO mice had cartilage damage comparable to WT mice. TLR5KOΔMicrobiota mice had less cartilage damage than other groups. HFD mice had elevated serum inflammatory markers. Each group had a distinct gut microbiome composition.

conclusionsSevere obesity increased load-induced cartilage damage, while milder changes in adiposity/metabolic syndrome seen in TLR5KO mice did not. Furthermore, the effects of systemic inflammation/obesity on cartilage damage depend on the duration of mechanical loading. Lastly, reduced cartilage damage in the TLR5KOΔMicrobiota mice suggests that the gut microbiome may influence cartilage pathology.

Indexed as

Gastrointestinal MicrobiomeAdipose TissueAnimalsArthritis, ExperimentalBiomarkersBody Mass IndexCartilage, ArticularCytokinesInflammation MediatorsLipopolysaccharidesMaleMetabolic SyndromeMice, Inbred C57BLMice, KnockoutObesityOsteoarthritisBiomarkersCytokinesInflammation MediatorsLipopolysaccharidesTlr5 protein, mouseToll-Like Receptor 5BoneGut microbiomeInflammationMechanical loadsObesityOsteoarthritis

Identifiers

PMID30240938
PMCPMC6309743
OpenAlexW2890313526

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.