Evidence map›Paper›PMID 30240926›Full record

ArticlePhotodiagnosis and photodynamic therapy2018

Combined CB2 receptor agonist and photodynamic therapy synergistically inhibit tumor growth in triple negative breast cancer.

Jiliang Zhang, Shaojuan Zhang, Yang Liu, Meng Su, Xiaoxi Ling, Funan Liu, Yinghui Ge, Mingfeng Bai

Abstract read
In one paragraph

Article in Photodiagnosis and photodynamic therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Selective CBPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
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  6. Review
  7. Article
  8. Article
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  10. Article
  11. Article
  12. Review
  13. A Guide to Targeting the Endocannabinoid System in Drug Design.International journal of molecular sciences · 2020
    Review
  14. Article
  15. Future Aspects for Cannabinoids in Breast Cancer Therapy.International journal of molecular sciences · 2019
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Jiliang ZhangDepartment of Radiology, Fuwai Central China Cardiovascular Hospital, #1 Fuwai Road, Zhengzhou, Henan Province, 450000, China.
Shaojuan ZhangDepartment of Radiology, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA, 15219, USA.
Yang LiuVanderbilt University Institute of Imaging Sciences, Nashville, TN, 37232, USA.
Meng SuVanderbilt University Institute of Imaging Sciences, Nashville, TN, 37232, USA.
Xiaoxi LingDepartment of Radiology, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA, 15219, USA.
Funan LiuDepartment of Surgical Oncology and General Surgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Yinghui GeDepartment of Radiology, Fuwai Central China Cardiovascular Hospital, #1 Fuwai Road, Zhengzhou, Henan Province, 450000, China. Electronic address: cjr.geyinghui@vip.163.com.
Mingfeng BaiDepartment of Radiology, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA, 15219, USA; Department of Medicine, University of Pittsburgh, 3501 Fifth Ave, Pittsburgh, PA, 15213, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA; University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15232, USA. Electronic address: mingfeng.bai@vanderbilt.edu.
University of Pittsburgh · USVanderbilt University · USZhengzhou Central Hospital · CNChina Medical University · CNUPMC Hillman Cancer Center · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
A Novel Theranostic Platform for Targeted Cancer Therapy and Treatment MonitoringR21CA174541 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAI, MINGFENG · 2013 to 2015
$661k
NCI NIH HHS P30 CA047904NCI NIH HHS R21 CA174541
6 · The paper itself

Abstract

Triple negative breast cancer (TNBC) is the deadliest form of breast cancer because it is more aggressive, diagnosed at later stage and more likely to develop local and systemic recurrence. Many patients do not experience adequate tumor control after current clinical treatments involving surgical removal, chemotherapy and/or radiotherapy, leading to disease progression and significantly decreased quality of life. Here we report a new combinatory therapy strategy involving cannabinoid-based medicine and photodynamic therapy (PDT) for the treatment of TNBC. This combinatory therapy targets two proteins upregulated in TNBC: the cannabinoid CB2 receptor (CB

Indexed as

AcetamidesAnimalsApoptosisCell Line, TumorCell ProliferationCell SurvivalCombined Modality TherapyFemaleGene Expression Regulation, NeoplasticHumansIndolesMiceNeoplasm Recurrence, LocalPhenyl EthersPhotochemotherapyPhotosensitizing AgentsAcetamidesDAA 1106IndolesPhenyl EthersPhotosensitizing AgentsReceptor, Cannabinoid, CB2Receptors, GABASinglet OxygenTSPO protein, humanAgonistCannabinoidCB2 receptorCombination therapyPhotodynamic therapySynergisticTriple negative breast cancer

Identifiers

PMID30240926
PMCPMC6289793
OpenAlexW2892226899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.