ArticleNeuropharmacology2018
Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression.
Abstract read
In one paragraph
Article in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Investigational Drugs for the Treatment of Depression (Part 1): Monoaminergic, Orexinergic, GABA-Ergic, and Anti-Inflammatory Agents.Frontiers in pharmacology · 2022Pooled it
- Functional Plasticity of Orexin/Hypocretin Neurons Balances Stress States.Biological psychiatry · 2026Review
- Selective orexin receptor cross-over treatment increases resilience and expression of neuroplastic signaling genes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The Neural Network of Orexin-A: Implications in Feeding Regulation and Obesity-Anxiety Comorbidity.Brain sciences · 2026Review
- Social defeat stress responses in the stress alternative model are dependent on sex and anterior basolateral amygdala orexin 2 receptors.Biology of sex differences · 2026Article
- Acute carbamoylated erythropoietin reduces social stress-induced anxiety and depression-related behaviors.Neuropharmacology · 2025Article
- Aggression as a contributing factor to social defeat and stress vulnerability.Neurobiology of stress · 2025Article
- Learned phenotypes emerge during social stress modifying hippocampal orexin receptor gene expression.Scientific reports · 2024Article
- Hypocretin in the nucleus accumbens shell modulates social approach in female but not male California mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Regulation of neuronal plasticity associated with neuropsychiatric disorders by the orexinergic system.Heliyon · 2024Review
- Single administration of a psychedelic [(R)-DOI] influences coping strategies to an escapable social stress.Neuropharmacology · 2024Article
- Heightened SAM- and HPA-axis activity during acute stress impairs decision-making: A systematic review on underlying neuropharmacological mechanisms.Neurobiology of stress · 2024Article
- Understanding the Biological Relationship between Migraine and Depression.Biomolecules · 2024Review
- The Changed Nocturnal Sleep Structure and Higher Anxiety, Depression, and Fatigue in Patients with Narcolepsy Type 1.Nature and science of sleep · 2024Article
- The role of the orexin system in the neurobiology of anxiety disorders: Potential for a novel treatment target.Neuroscience applied · 2024Review
- Orexin Receptor Antagonists as Adjunct Drugs for the Treatment of Depression: A Mini Meta-Analysis.Noro psikiyatri arsivi · 2024Review
- Characteristics of Seltorexant-Innovative Agent Targeting Orexin System for the Treatment of Depression and Anxiety.Molecules (Basel, Switzerland) · 2023Review
- Resilience and its correlates in patients with narcolepsy type 1.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Anxiolytic reversal of classically conditioned / chronic stress-induced gene expression and learning in the Stress Alternatives Model.Behavioural brain research · 2023Article
- Contextual generalization of social stress learning is modulated by orexin receptors in basolateral amygdala.Neuropharmacology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Clarissa D StatonDepartment of Biology, University of South Dakota, Vermillion, SD 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, SD 57105, USA.
Jazmine D W YaegerDepartment of Biology, University of South Dakota, Vermillion, SD 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, SD 57105, USA.
Delan KhalidDepartment of Biology, University of South Dakota, Vermillion, SD 57069, USA; Department of Biology, University of Massachusetts, Boston, 100William T. Morrissey Blvd, Boston, MA 02125, USA.
Fadi HarounDepartment of Biology, University of South Dakota, Vermillion, SD 57069, USA; Department of Biology, University of Utah, 257 South 1400 East, Rm. 201 Salt Lake City, UT 84112-0840, USA.
Belissa S FernandezDepartment of Biology, University of South Dakota, Vermillion, SD 57069, USA.
Jessica S FernandezDepartment of Biology, University of South Dakota, Vermillion, SD 57069, USA.
Bali K SummersVermillion High School, 1001 E Main Street, Vermillion, SD 57069, USA; Department of Chemistry, Colorado State University, 1301 Center Ave Campus Delivery 1872, Ft. Collins, CO 80523-1872, USA.
Tangi R SummersDepartment of Biology, University of South Dakota, Vermillion, SD 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, SD 57105, USA.
Monica SathyanesanNeuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Samuel S NewtonNeuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Cliff H SummersDepartment of Biology, University of South Dakota, Vermillion, SD 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, SD 57105, USA. Electronic address: cliff@usd.edu.
Funding
Trophic Factors in CognitionR01MH106640 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SATHYANESAN, SAMUEL NEWTON · 2016 to 2025
$3.7MAmygdalar Orexin Modulation of Affective DisordersR15MH104485 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SUMMERS, CLIFF H · 2015 to 2015
$426kNIMH NIH HHS R01 MH106640NIMH NIH HHS R15 MH104485
Abstract
Knockdown of orexin/hypocretin 2 receptor (Orx
Indexed as
AmygdalaAnimalsAnxietyConditioning, PsychologicalDepressionFearFreezing Reaction, CatalepticMaleMice, Inbred C57BLNeuronsOrexin Receptor AntagonistsOrexin ReceptorsOrexinsPsychotropic DrugsReflex, StartleResilience, PsychologicalOrexin Receptor AntagonistsOrexin ReceptorsOrexinsPsychotropic Drugs[Ala11, d-Leu15]–Orx(B), a modified Orx(B) peptide used as an Orx(2) receptor agonistAnxietyDefeatDepressionFear conditioningFreezingHypocretinMK-1064, 5″-chloro-N-[(5,6-dimethoxy-2-pyridinyl)methyl]-[2,2':5′,3″-terpyridine]-3′-carboxamide - an Orx(2) antagonistResilienceStartleStress Alternatives ModelSusceptibility
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.