ArticleThe Journal of allergy and clinical immunology2019
Severe bronchiolitis profiles and risk of recurrent wheeze by age 3 years.
Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Respiratory virus type to guide predictive enrichment approaches in the management of the first episode of bronchiolitis: A systematic review.Frontiers in immunology · 2022Pooled it
- Respiratory Virus Epidemiology Among US Infants With Severe Bronchiolitis: Analysis of 2 Multicenter, Multiyear Cohort Studies.The Pediatric infectious disease journal · 2019Pooled it
- Effect of Avoiding Cow's Milk Formula at Birth on Prevention of Asthma or Recurrent Wheeze Among Young Children: Extended Follow-up From the ABC Randomized Clinical Trial.JAMA network open · 2020Trial
- Acute Severity Versus Long-term Morbidity: Uncoupling the Roles of RSV and HRV in Childhood Respiratory Disease.Open forum infectious diseases · 2026Article
- Wheezing on admission: a marker for bronchiolitis severity and asthma development.Pediatric research · 2025Article
- Risk Factors and Mechanisms Leading to Preschool Recurrent Wheeze and Asthma.The journal of allergy and clinical immunology. In practice · 2025Review
- Predictive Factors and Clinical Markers of Recurrent Wheezing and Asthma After RSV Infection.Viruses · 2025Review
- Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life Experience.Viruses · 2025Article
- Risk factors for recurrent wheezing after infant bronchiolitis: a 6-year single-centre follow up study in China.Frontiers in pediatrics · 2025Article
- Early risk identification for recurrent wheezing in children with respiratory syncytial virus infections.American journal of translational research · 2025Article
- Association between nasopharyngeal airway lipidome signatures of infants with severe bronchiolitis and risk of recurrent wheeze: A prospective multicenter cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Article
- How does post COVID differ from other post-viral conditions in childhood and adolescence (0-20 years old)? A systematic review.EClinicalMedicine · 2024Article
- Association of rhinovirus and potentially pathogenic bacterial detections in the first 3 months of life with subsequent wheezing in childhood.Pediatric pulmonology · 2023Article
- Gut microecological regulation on bronchiolitis and asthma in children: A review.The clinical respiratory journal · 2023Review
- Prenatal exposure to RSV season influences first-year risk of RSV lower respiratory illness and RSV-specific immune responses assessed at birth.Journal of virology · 2023Article
- Application of Asthma Prediction Tools in a Cohort of Infants with Severe Bronchiolitis.Pediatric allergy, immunology, and pulmonology · 2023Article
- Case-control study of exclusive breast feeding and severe bronchiolitis in the United States.Paediatric and perinatal epidemiology · 2023Article
- Risk factors for recurrent wheezing after bronchiolitis.BMC pediatrics · 2023Article
- Bacterial Microbiota of Asthmatic Children and Preschool Wheezers' Airways-What Do We Know?Microorganisms · 2023Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundA better understanding of bronchiolitis heterogeneity might help clarify its relationship with the development of recurrent wheezing and asthma.
objectivesWe sought to identify severe bronchiolitis profiles using a clustering approach and to investigate for the first time their association with allergy/inflammatory biomarkers, nasopharyngeal microbiota, and development of recurrent wheezing by age 3 years.
methodsWe analyzed data from a prospective, 17-center US cohort study of 921 infants (age <1 year) hospitalized with bronchiolitis (2011-2014 winters) with posthospitalization follow-up. Severe bronchiolitis profiles at baseline (hospitalization) were determined by using latent class analysis based on clinical factors and viral etiology. Blood biomarkers and nasopharyngeal microbiota profiles were determined by using samples collected within 24 hours of hospitalization. Recurrent wheezing by age 3 years was defined based on parental report of breathing problem episodes after discharge.
resultsThree severe bronchiolitis profiles were identified: profile A (15%), which was characterized by a history of breathing problems/eczema during infancy and non-respiratory syncytial virus (mostly rhinovirus) infection; profile B (49%), which has the largest probability of respiratory syncytial virus infection and resembled classic respiratory syncytial virus-induced bronchiolitis; and profile C (36%), which was composed of the most severely ill group. Profile A infants had higher eosinophil counts, higher cathelicidin levels, and increased proportions of Haemophilus-dominant or Moraxella-dominant microbiota profiles. Compared with profile B, we observed significantly increased risk of recurrent wheezing in children with profile A (hazard ratio, 2.64; 95% CI, 1.90-3.68) and, to a lesser extent, with profile C (hazard ratio, 1.51; 95% CI, 1.14-2.01).
conclusionAlthough longer follow-up is needed, our results might help identify, among children hospitalized for bronchiolitis, subgroups with particularly increased risk of asthma.
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