Evidence map›Paper›PMID 30240676›Full record

ArticleJournal of molecular and cellular cardiology2018

β-adrenergic regulation of late Na

Bence Hegyi, Tamás Bányász, Leighton T Izu, Luiz Belardinelli, Donald M Bers, Ye Chen-Izu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Conductance Changes of NaPharmaceuticals (Basel, Switzerland) · 2023
    Article
  12. BIOLOGICAL ANTIARRHYTHMICS-SODIUM CHANNEL INTERACTING PROTEINS.Transactions of the American Clinical and Climatological Association · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Late NaPharmaceuticals (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Bence HegyiDepartment of Pharmacology, University of California, Davis, CA, USA. Electronic address: bhegyi@ucdavis.edu.
Tamás BányászDepartment of Pharmacology, University of California, Davis, CA, USA; Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Leighton T IzuDepartment of Pharmacology, University of California, Davis, CA, USA.
Luiz BelardinelliGilead Sciences, Inc., Foster City, CA, USA.
Donald M BersDepartment of Pharmacology, University of California, Davis, CA, USA.
Ye Chen-IzuDepartment of Pharmacology, University of California, Davis, CA, USA; Department of Biomedical Engineering, University of California, Davis, CA, USA; Department of Internal Medicine/Cardiology, University of California, Davis, CA, USA. Electronic address: ychenizu@ucdavis.edu.
University of California, Davis · USGilead Sciences (United States) · US

Funding

Phospholemman and Na-Pump Function in Cardiac MyocytesR01HL081562 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2005 to 2018
$5.3M
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8M
MECHANICAL LOAD EFFECT ON CARDIAC EXCITATION-CONTRACTION COUPLINGR01HL141460 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2019 to 2022
$2.6M
AKAP-dependent regulation of Cardiac SR Ca handlingR01HL133832 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2017 to 2020
$2.0M
Novel Cell-in-Gel System for Mechanotransduction Study at the Single Cell LevelR01HL123526 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2015 to 2018
$1.8M
Decipher Mechano-Chemo-Transduction Pathway and Function in CardiomyocytesR01HL159993 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2021 to 2022
$1.5M
Sarcomere Length Shortening and the Destabilization of the Ca2+ Control System inR01HL090880 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IZU, LEIGHTON T. · 2009 to 2012
$1.5M
NHLBI NIH HHS R01 HL030077NHLBI NIH HHS R01 HL081562NHLBI NIH HHS R01 HL090880NHLBI NIH HHS R01 HL123526NHLBI NIH HHS R01 HL133832NHLBI NIH HHS R01 HL141460NHLBI NIH HHS R01 HL159993
6 · The paper itself

Abstract

Late Na

Indexed as

Action PotentialsAnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingCyclic AMP-Dependent Protein KinasesElectrophysiological PhenomenaMyocytes, CardiacNitric Oxide SynthaseRabbitsReactive Oxygen SpeciesReceptors, Adrenergic, betaSodiumTetrodotoxinCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP-Dependent Protein KinasesNitric Oxide SynthaseReactive Oxygen SpeciesReceptors, Adrenergic, betaSodiumTetrodotoxinAction potentialBeta-adrenergic stimulationCa(2+)/calmodulin-dependent kinase IILate sodium currentNitric oxide synthaseProtein kinase A

Identifiers

PMID30240676
PMCPMC6201263
OpenAlexW2890459934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.