ArticleiScience2018
Highly Selective Transmission Success of Dengue Virus Type 1 Lineages in a Dynamic Virus Population: An Evolutionary and Fitness Perspective.
Article in iScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Assessing the Risk of Dengue Virus Local Transmission: Study on Vector Competence of ItalianViruses · 2024Article
- Singapore's 5 decades of dengue prevention and control-Implications for global dengue control.PLoS neglected tropical diseases · 2023Article
- Genetic Diversity and Dispersal of DENGUE Virus among Three Main Island Groups of the Philippines during 2015-2017.Viruses · 2023Article
- Is new dengue vaccine efficacy data a relief or cause for concern?NPJ vaccines · 2023Review
- Molecular surveillance of arboviruses circulation and co-infection during a large chikungunya virus outbreak in Thailand, October 2018 to February 2020.Scientific reports · 2022Article
- Lineage Replacement Associated with Fitness Gain in Mammalian Cells andMicroorganisms · 2022Article
- Genetic Diversity of Dengue Virus in Clinical Specimens from Bangkok, Thailand, during 2018-2020: Co-Circulation of All Four Serotypes with Multiple Genotypes and/or Clades.Tropical medicine and infectious disease · 2021Article
- A Cluster of Dengue Cases in Travelers: A Clinical Series from Thailand.Tropical medicine and infectious disease · 2021Article
- Novel and emerging mutations of SARS-CoV-2: Biomedical implications.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Review
- Molecular evolution of dengue virus types 1 and 4 in Korean travelers.Archives of virology · 2021Article
- Detection of Japanese Encephalitis Virus inThe American journal of tropical medicine and hygiene · 2020Article
- Positive epistasis between viral polymerase and the 3' untranslated region of its genome reveals the epidemiologic fitness of dengue virus.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Development of a Standardized Sanger-Based Method for Partial Sequencing and Genotyping of Dengue Viruses.Journal of clinical microbiology · 2019Article
- Circulation of dengue serotype 1 viruses during the 2019 outbreak in Dar es Salaam, Tanzania.Pathogens and global healthArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arbovirus transmission is modulated by host, vector, virus, and environmental factors. Even though viral fitness plays a salient role in host and vector adaptation, the transmission success of individual strains in a heterogeneous population may be stochastic. Our large-scale molecular epidemiological analyses of a dengue virus type 1 population revealed that only a subset of strains (16.7%; n = 6) were able to sustain transmission, despite the population being widely dispersed, dynamic, and heterogeneous. The overall dominance was variable even among the "established" lineages, albeit sharing comparable evolutionary characteristics and replication profiles. These findings indicated that virological parameters alone were unlikely to have a profound effect on the survival of viral lineages, suggesting an important role for non-viral factors in the transmission success of lineages. Our observations, therefore, emphasize the strategic importance of a holistic understanding of vector, human host, and viral factors in the control of vector-borne diseases.
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