ArticleHuman brain mapping2018
Education, and the balance between dynamic and stationary functional connectivity jointly support executive functions in relapsing-remitting multiple sclerosis.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- A technical review of canonical correlation analysis for neuroscience applications.Human brain mapping · 2020Pooled it
- Dynamic properties in functional connectivity changes and striatal dopamine deficiency in Parkinson's disease.Human brain mapping · 2024Article
- Emerging Perspectives on MRI Application in Multiple Sclerosis: Moving from Pathophysiology to Clinical Practice.Radiology · 2023Review
- Graph-Based Analysis of Brain Connectivity in Multiple Sclerosis Using Functional MRI: A Systematic Review.Brain sciences · 2023Review
- Microstates in multiple sclerosis: an electrophysiological signature of altered large-scale networks functioning?Brain communications · 2023Article
- Symptom Interconnectivity in Multiple Sclerosis: A Narrative Review of Potential Underlying Biological Disease Processes.Neurology and therapy · 2022Review
- Article
- The network collapse in multiple sclerosis: An overview of novel concepts to address disease dynamics.NeuroImage. Clinical · 2022Review
- A more unstable resting-state functional network in cognitively declining multiple sclerosis.Brain communications · 2022Article
- Tools of the trade: estimating time-varying connectivity patterns from fMRI data.Social cognitive and affective neuroscience · 2021Review
- Mind the gap: from neurons to networks to outcomes in multiple sclerosis.Nature reviews. Neurology · 2021Review
- Disrupted Dynamic Functional Connectivity in Distinguishing Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment Based on the Triple-Network Model.Frontiers in aging neuroscience · 2021Article
- Structural and Functional Connectivity Substrates of Cognitive Impairment in Multiple Sclerosis.Frontiers in neurology · 2021Review
- Article
- Reproducibility of graph measures at the subject level using resting-state fMRI.Brain and behavior · 2020Article
- Multi-scale resting state functional reorganization in response to multiple sclerosis damage.Neuroradiology · 2020Article
- Determining the number of states in dynamic functional connectivity using cluster validity indexes.Journal of neuroscience methods · 2020Article
- Dynamic Neuroimaging Biomarkers of Smoking in Young Smokers.Frontiers in psychiatry · 2020Article
- Both Stationary and Dynamic Functional Interhemispheric Connectivity Are Strongly Associated With Performance on Cognitive Tests in Multiple Sclerosis.Frontiers in neurology · 2020Article
- Characterizing Rapid Fluctuations of Resting State Functional Connectivity in Demyelinating, Neurodegenerative, and Psychiatric Conditions: From Static to Time-Varying Analysis.Frontiers in neuroscience · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graphical network characteristics and nonstationary functional connectivity features, both derived from resting-state functional magnetic resonance imaging (rsfMRI) data, have been associated with cognitive performance in healthy subjects. How these features jointly relate to cognition in diseased states has not been investigated. In this study, 46 relapsing-remitting multiple sclerosis subjects underwent rsfMRI scans and a focused cognitive battery. With a sliding window approach, we examined six dynamic network features that indicated how connectivity changed over time as well as six measures derived from graph theory to reflect static network characteristics. Multiset canonical correlation analysis (MCCA) was then carried out to investigate the relations between dynamic network features, stationary network characteristics, cognitive testing, demographic, disease severity, and mood. Multiple sclerosis (MS) subjects demonstrated weaker connectivity strength, decreased network density, reduced global changes, but increased changes in interhemispheric connectivity compared to controls. The MCCA model determined that executive functions and processing speed ability measured by Wechsler Adult Intelligence Scale IV (WAIS-IV) Working Memory Index, WAIS-IV Processing Speed Index, and the Verbal Fluency Test were positively correlated with education, dynamic connectivity, and static connectivity strength; while poor task switching was correlated with disease severity, psychiatric comorbidities such as depression, anxiety, and fatigue, and static network density. Taken together, our results suggest that better executive functioning in MS requires maintenance of a continued coordination between stationary and dynamic functional connectivity as well as the support of education, and dynamic functional connectivity may provide an additional cognitive biomarker of disease severity in the MS population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.