Evidence map›Paper›PMID 30240346›Full record

ReviewPhysiological genomics2018

Epigenetics of metabolic syndrome.

Caryn Carson, Heather A Lawson

Abstract readReview
In one paragraph

Review in Physiological genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Frontiers in nutrition · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Metabolic syndrome and epigenetic aging: a twin study.International journal of obesity (2005) · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Epigenetics · 2021
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Caryn CarsonDepartment of Genetics, Washington University School of Medicine , Saint Louis, Missouri.
Heather A LawsonDepartment of Genetics, Washington University School of Medicine , Saint Louis, Missouri.

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Irfan J Lodhi · 2013 to 2026
$27.1M
TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
IDENTIFYING SIGNATURES OF IMPRINTING EFFECTS ASSOCIATED WITH OBESITY AND T2DK01DK095003 · NIDDK · WASHINGTON UNIVERSITY · PI LAWSON, HEATHER A. · 2013 to 2016
$492k
NIDDK NIH HHS K01 DK095003NIDDK NIH HHS P30 DK020579NIGMS NIH HHS T32 GM007067
6 · The paper itself

Abstract

The dramatic increase in global prevalence of metabolic disease is inexplicable when considering only environmental or only genetic factors, leading to the need to explore the possible roles of epigenetic factors. A great deal of progress has been made in this interdisciplinary field in recent years, with many studies investigating various aspects of the metabolic syndrome and its associated epigenetic changes. Rodent models of metabolic diseases have been particularly illuminating because of the ability to leverage tools such as genetic and environmental modifications. The current review summarizes recent breakthroughs regarding epigenetic markers in studies of obesity, Type II diabetes, and cardiovascular disease, the three major disorders associated with metabolic syndrome. We also discuss open questions and future directions for integrating genomic, epigenomic, and phenotypic big biodata toward understanding metabolic syndrome etiology.

Indexed as

Epigenesis, GeneticAnimalsChromatinDiabetes Mellitus, Type 2DNA MethylationHistonesHumansMetabolic SyndromeObesityRNA, UntranslatedChromatinHistonesRNA, Untranslatedcardiovascular diseasechromatinepigeneticshistone modificationsmetabolic syndromemethylationnon-coding RNAobesityType II diabetes

Identifiers

PMID30240346
PMCPMC6293117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.