ArticleJournal of agricultural and food chemistry2018
Oral Administration of Salecan-Based Hydrogels for Controlled Insulin Delivery.
Article in Journal of agricultural and food chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 133 citations in OpenAlex.
- Review
- Polymeric Nanocarrier-Based Drug Formulations for Enhancing Nose-to-Brain Delivery.Pharmaceutics · 2025Review
- Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs.Drug design, development and therapy · 2024Review
- A review on oral novel delivery systems of insulin through the novel delivery system formulations: A review.SAGE open medicine · 2024Review
- Polymer-Based Hydrogels Applied in Drug Delivery: An Overview.Gels (Basel, Switzerland) · 2023Review
- A pH responsive and superporous biocomposite hydrogel ofRSC advances · 2023Article
- Article
- Biosorption Characteristic and Cytoprotective Effect of PbMolecules (Basel, Switzerland) · 2022Article
- Preparation and Properties of Salecan-Soy Protein Isolate Composite Hydrogel Induced by Thermal Treatment and Transglutaminase.International journal of molecular sciences · 2022Article
- Review
- Synthesis and Rheological Characterization of a Novel Salecan Hydrogel.Pharmaceutics · 2022Article
- Emerging Fabrication Strategies of Hydrogels and Its Applications.Gels (Basel, Switzerland) · 2022Review
- Versatile Oral Insulin Delivery Nanosystems: From Materials to Nanostructures.International journal of molecular sciences · 2022Review
- Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles.Science advances · 2022Article
- Acrylate and Methacrylate Polymers' Applications: Second Life with Inexpensive and Sustainable Recycling Approaches.Materials (Basel, Switzerland) · 2021Review
- A Bio-Based Hydrogel Derived from Moldy Steamed Bread as Urea-Formaldehyde Loading for Slow-Release and Water-Retention Fertilizers.ACS omega · 2021Article
- Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(Molecules (Basel, Switzerland) · 2021Article
- Bacteria-Based Microdevices for the Oral Delivery of Macromolecules.Pharmaceutics · 2021Review
- Evaluation of the Antitumor Effect and Immune Response of Micelles Modified with a Polysialic Acid-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate Conjugate.AAPS PharmSciTech · 2021Article
- Mussel-inspired agarose hydrogel scaffolds for skin tissue engineering.Bioactive materials · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We present an improved type of food gum (salecan) based hydrogels for oral delivery of insulin. Structural hydrogel formation was assessed with Fourier transform infrared spectroscopy, thermogravimetric analysis, and X-ray diffraction. We found that the hydrogel modulus, morphology, and swelling properties can be controlled by varying the salecan dose during hydrogel formation. Insulin was introduced into the hydrogel using a swelling-diffusion approach and then further used a drug prototype. In vitro insulin release profiles demonstrated that the release of entrapped insulin was suppressed in acidic conditions but markedly increased at neutral pH. Cell viability and toxicity tests revealed that the salecan hydrogel constructs were biocompatible. Oral administration of insulin-loaded salecan hydrogels in diabetic rats resulted in a sustained decrease of fasting plasma glucose levels over 6 h postadministration. For nondiabetic animals, the relative pharmacological bioavailability of insulin was significantly larger (6.24%, p < 0.05) for insulin-loaded hydrogels compared to free insulin. These results encourage further development of salecan-based hydrogels as vehicles for controlled insulin delivery following oral administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.