Evidence map›Paper›PMID 30240027›Full record

ArticleSynapse (New York, N.Y.)2019

Imaging phosphodiesterase-10a availability in cocaine use disorder with [

Savannah Tollefson, Joshua Gertler, Michael L Himes, Jennifer Paris, Steve Kendro, Brian Lopresti, N Scott Mason, Rajesh Narendran

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synapse (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Savannah TollefsonDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Joshua GertlerDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Michael L HimesDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jennifer ParisDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Steve KendroDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Brian LoprestiDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
N Scott MasonDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Rajesh NarendranDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-4292-2850
University of Pittsburgh · US

Funding

PET Imaging of neurochemical transmission in cocaine use disordersR01DA026472 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NARENDRAN, RAJESH · 2009 to 2025
$7.7M
Imaging Nociceptin Receptors in AlcoholismR01AA025247 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NARENDRAN, RAJESH · 2016 to 2019
$2.4M
NIAAA NIH HHS R01 AA025247NIDA NIH HHS R01 DA026472
6 · The paper itself

Abstract

Phosphodiesterase-10a (PDE10a) is located exclusively in medium spiny neurons (MSN). Rodent studies show an increase in striatal MSN spine density following exposure to cocaine. These increases in MSN spine density are suggested to underlie neurobiological changes which contribute to cocaine self-administration. No postmortem or imaging studies have confirmed this finding in humans. Here, we hypothesized an increase in the MSN marker PDE10a in subjects with cocaine use disorder ("cocaine users") compared to controls. PDE10a availability was measured with [

Indexed as

AdolescentAdultBrainCocaine-Related DisordersFemaleHeterocyclic Compounds, 2-RingHumansMaleMiddle AgedPhosphoric Diester HydrolasesPositron-Emission TomographyQuinoxalinesRadiopharmaceuticalsHeterocyclic Compounds, 2-RingIMA107PDE10A protein, humanPhosphoric Diester HydrolasesQuinoxalinesRadiopharmaceuticals[11C]IMA107cocaine use disordersmedium spiny neuronsphosphodiesterase-10a (PDE 10a)positron emission tomography

Identifiers

PMID30240027
PMCPMC6235703
OpenAlexW2892949766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.