ArticleSchizophrenia bulletin2019
Impaired Right Temporoparietal Junction-Hippocampus Connectivity in Schizophrenia and Its Relevance for Generating Representations of Other Minds.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Competitive Bias in Severe Alcohol Use Disorder: An Exploration Through the Prisoner's Dilemma Paradigm.Alcohol, clinical & experimental research · 2026Article
- Behavioral differences in cooperation between patients with schizophrenia and control participants.Scientific reports · 2026Article
- Causal roles of prefrontal and temporo-parietal theta oscillations for inequity aversion.Social cognitive and affective neuroscience · 2023Article
- Aberrant intra- and internetwork functional connectivity patterns of the anterior and posterior hippocampal networks in schizophrenia.CNS neuroscience & therapeutics · 2023Article
- Every individual makes a difference: A trinity derived from linking individual brain morphometry, connectivity and mentalising ability.Human brain mapping · 2023Article
- Review
- The Transdiagnostic Relevance of Self-Other Distinction to Psychiatry Spans Emotional, Cognitive and Motor Domains.Frontiers in psychiatry · 2022Article
- Antagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas.Scientific reports · 2021Article
- Strategies to solve the reverse inference fallacy in future MRI studies of schizophrenia: a review.Brain imaging and behavior · 2021Review
- Cognitive Empathy and Longitudinal Changes in Temporo-Parietal Junction Thickness in Schizophrenia.Frontiers in psychiatry · 2021Article
- Neural Correlates of Mentalizing in Individuals With Clinical High Risk for Schizophrenia: ALE Meta-Analysis.Frontiers in psychiatry · 2021Review
- Impaired Cognitive Abilities in Siblings of Patients with Temporal Lobe Epilepsy.Neuropsychiatric disease and treatment · 2020Article
- Stria terminalis, amygdala, and temporoparietal junction networks facilitate efficient emotion processing under expectations.Human brain mapping · 2019Article
- Predictive Modulation of Corticospinal Excitability and Implicit Encoding of Movement Probability in Schizophrenia.Schizophrenia bulletin · 2019Article
- Nonsocial and social cognition in schizophrenia: current evidence and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2019Article
- fMRI biomarkers of social cognitive skills training in psychosis: Extrinsic and intrinsic functional connectivity.PloS one · 2019Article
- Vestibular and Multi-Sensory Influences Upon Self-Motion Perception and the Consequences for Human Behavior.Frontiers in neurology · 2019Review
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is associated with impaired and exaggerated Theory of Mind processes, pointing on alterations in generating a representation of another person's mind. Despite recent work on healthy subjects suggesting that a coupling between the right temporoparietal junction (rTPJ) and the hippocampus is relevant for building representations of others' intentions, the neural basis of related dysfunctions in patients with schizophrenia remains unclear. Therefore, we used structural and functional magnetic resonance imaging together with a modified prisoner's dilemma game to test the hypotheses, that patients show dysfunctional social updating on behavioral level accompanied by altered rTPJ-hippocampus coupling on a functional and a structural level. During the task, 31 patients with schizophrenia and 20 healthy controls interacted with 3 playing partners, who behaved according to stable strategies competitively, cooperatively, or randomly. Our data show that patients adapted their social behavior less flexibly to the playing partners than healthy controls, indicating differences in forming mental representations of the counterparts' intentions. Patients showed lower functional connectivity between the rTPJ and temporal lobe regions such as the hippocampus, the fusiform gyrus, and the middle temporal gyrus, indicating that in patients the rTPJ fails to integrate memory-informed processing streams during mental state inferences. Remarkably, the rTPJ-hippocampus coupling accounted for the participants' adaptive social behavior in the task, suggesting that a neural pathway relevant for updating social knowledge and forming forward predictions in social interactions is altered in schizophrenia.
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