ArticleNucleic acids research2018
Salicylic acid-induced transcriptional reprogramming by the HAC-NPR1-TGA histone acetyltransferase complex in Arabidopsis.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 112 citations in OpenAlex.
- A positive feedback loop between NPR1 and SOG1 reinforces genotoxic tolerance in Arabidopsis.Plant communications · 2026Article
- LURP1, a SARD1-regulated protein, coordinates with the helper NLR ADR1 to promote plant immunity.The New phytologist · 2026Article
- Chromatin accessibility and histone landscapes define immune signal-specific transcriptional reprogramming inaBIOTECH · 2026Article
- Acibenzolar-Journal of pesticide science · 2026Article
- DELLA proteins interact with HAC1 and control plant growth via transcriptional regulation of the growth repressor gene ERF2.The Plant cell · 2026Article
- Amino acid vectorization of salicylic acid enables efficient activation of NPR1-dependent defense without phytotoxicity.Pest management science · 2026Article
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Pan-genomic and transcriptomic analyses reveal subfunctionalization of CBP/p300-like histone acetyltransferases in soybean seed development.BMC plant biology · 2026Article
- Comprehensive analysis of TGA genes in barley: structure, evolution, and stress-responsive expression.BMC plant biology · 2026Article
- Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions.Molecular biomedicine · 2026Review
- Insects manipulate host nuclear trafficking and epigenetic regulation to facilitate herbivory.Nature communications · 2026Article
- Leaf it to science: Uncovering plant immune systems through technological advances.Plant physiology · 2026Review
- How to improve crop pathogen resistance with epigenetics.Phytopathology research · 2026Review
- Cellular energy sensor SnRK1 suppresses salicylic acid-dependent and -independent defenses and bacterial resistance inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Genome-Wide Identification and Analysis of bZIP Transcription Factor Gene Family in Broomcorn Millet (Genes · 2025Article
- Modulation of Plant Interactions with Whitefly and Whitefly-Borne Viruses by Salicylic Acid Signaling Pathway: A Review.Viruses · 2025Review
- H3K4me3 binding ALFIN-LIKE proteins recruit SWR1 for gene-body deposition of H2A.Z.Genome biology · 2025Article
- The Role of Salicylic Acid in Activating Plant Stress Responses-Results of the Past Decade and Future Perspectives.International journal of molecular sciences · 2025Review
- GCN5-related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato.The New phytologist · 2025Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant immunity depends on massive expression of pathogenesis-related genes (PRs) whose transcription is de-repressed by pathogen-induced signals. Salicylic acid (SA) acts as a major signaling molecule in plant immunity and systemic acquired resistance triggered by bacterial or viral pathogens. SA signal results in the activation of the master immune regulator, Nonexpressor of pathogenesis-related genes 1 (NPR1), which is thought to be recruited by transcription factors such as TGAs to numerous downstream PRs. Despite its key role in SA-triggered immunity, the biochemical nature of the transcriptional coactivator function of NPR1 and the massive transcriptional reprogramming induced by it remain obscure. Here we demonstrate that the CBP/p300-family histone acetyltransferases, HACs and NPR1 are both essential to develop SA-triggered immunity and PR induction. Indeed HACs and NPR1 form a coactivator complex and are recruited to PR chromatin through TGAs upon SA signal, and finally the HAC-NPR1-TGA complex activates PR transcription by histone acetylation-mediated epigenetic reprogramming. Thus, our study reveals a molecular mechanism of NPR1-mediated transcriptional reprogramming and a key epigenetic aspect of the central immune system in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.