Observational studyNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2019
All-cause mortality in relation to changes in relative blood volume during hemodialysis.
Observational study in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Blood pressure and volume management in dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2020Guideline
- Toward Precision Fluid Management in Hemodialysis: Adaptive Ultrafiltration Guided by Continuous Relative Blood Volume Monitoring.Journal of clinical medicine · 2026Article
- Lower Hospitalization Rates During Fluid Management with Relative Blood Volume Monitoring: A Retrospective Cohort Analysis.Journal of clinical medicine · 2026Article
- Estimation of Intradialytic Blood Volume Reduction Using Hemoglobin Changes: A Prospective Validation Study of a Pragmatic Clinical Tool.Journal of clinical medicine · 2026Article
- Continuous monitoring of relative blood volume allows real-time assessment of intradialytic hypotension risk.Clinical kidney journal · 2026Article
- Linking Intradialytic Blood Volume Dynamics to Extracellular Fluid Status: Toward Personalized Fluid Assessment in Hemodialysis.Journal of clinical medicine · 2025Article
- Prediction Model of Intradialytic Hypertension in Hemodialysis Patients Based on Machine Learning.Journal of medical systems · 2025Article
- Utility of Central Venous Oxygen Saturation Gradient in Predicting Mortality in Dialysis with Catheter Access.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Technical requirements and devices available for long-term hemodialysis in children-mind the gap!Pediatric nephrology (Berlin, Germany) · 2024Review
- Review
- High Ferritin and Low Total Iron-Binding Capacity in Plasma Predict All-Cause Mortality During the First 3 Years of Hemodialysis in Patients with End-Stage Chronic Kidney Disease.International journal of general medicine · 2024Article
- Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation.Cells · 2023Article
- Fluid Overload and Tissue Sodium Accumulation as Main Drivers of Protein Energy Malnutrition in Dialysis Patients.Nutrients · 2022Review
- High Ultrafiltration Rates and Mortality in Hemodialysis Patients: Current Evidence and Future Steps.Kidney360 · 2022Article
- The associations between orthostatic blood pressure changes and extracellular volume in hemodialysis patients.Hemodialysis international. International Symposium on Home Hemodialysis · 2022Article
- Cognitive Domain Impairment and All-Cause Mortality in Older Patients Undergoing Hemodialysis.Frontiers in endocrinology · 2022Article
- Sodium First Approach, to Reset Our Mind for Improving Management of Sodium, Water, Volume and Pressure in Hemodialysis Patients, and to Reduce Cardiovascular Burden and Improve Outcomes.Frontiers in nephrology · 2022Review
- Real-time prediction of intradialytic relative blood volume: a proof-of-concept for integrated cloud computing infrastructure.BMC nephrology · 2021Article
- Integrating Monitoring of Volume Status and Blood Volume-Controlled Ultrafiltration into Extracorporeal Kidney Replacement Therapy.International journal of nephrology and renovascular disease · 2021Article
- The renal replacement therapy landscape in 2030: reducing the global cardiovascular burden in dialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRelative blood volume (RBV) monitoring is widely used in hemodialysis (HD) patients, yet the association between intradialytic RBV and mortality is unknown.
methodsIntradialytic RBV was recorded once/min during a 6-month baseline period; all-cause mortality was noted during follow-up. RBV at 1, 2 and 3 h into HD served as a predictor of all-cause mortality during follow-up. We employed Kaplan-Meier analysis, univariate and adjusted Cox proportional hazards models for survival analysis.
resultsWe studied 842 patients. During follow-up (median 30.8 months), 249 patients (29.6%) died. The following hourly RBV ranges were associated with improved survival: first hour, 93-96% [hazard ratio (HR) 0.58 (95% confidence interval (CI) 0.42-0.79)]; second hour, 89-94% [HR 0.54 (95% CI 0.39-0.75)]; third hour, 86-92% [HR 0.46 (95% CI 0.33-0.65)]. In about one-third of patients the RBV was within these ranges and in two-thirds it was above. Subgroup analysis by median age (≤/> 61 years), sex, race (white/nonwhite), predialysis systolic blood pressure (SBP; ≤/> 130 mmHg) and median interdialytic weight gain (≤/> 2.3 kg) showed comparable favorable RBV ranges. Patients with a 3-h RBV between 86 and 92% were younger, had higher ultrafiltration volumes and rates, similar intradialytic average and nadir SBPs and hypotension rates, lower postdialysis SBP and a lower prevalence of congestive heart failure when compared with patients with an RBV >92%. In the multivariate Cox analysis, RBV ranges remained independent and significant outcome predictors.
conclusionSpecific hourly intradialytic RBV ranges are associated with lower all-cause mortality in chronic HD patients.
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