Evidence map›Paper›PMID 30239814›Full record

ArticleThe Journal of infectious diseases2019

Azithromycin Susceptibility Among Neisseria gonorrhoeae Isolates and Seasonal Macrolide Use.

Scott W Olesen, Elizabeth A Torrone, John R Papp, Robert D Kirkcaldy, Marc Lipsitch, Yonatan H Grad

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Prior Exposure to Azithromycin and Azithromycin Resistance Among Persons Diagnosed With Neisseria gonorrhoeae Infection at a Sexual Health Clinic: 2012-2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  6. Review
  7. Review
  8. Frequency of bystander exposure to antibiotics for enteropathogenic bacteria among young children in low-resource settings.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Article
  11. The Distribution and Spread of Susceptible and Resistant Neisseria gonorrhoeae Across Demographic Groups in a Major Metropolitan Center.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  12. Review
  13. The role of "spillover" in antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Scott W OlesenDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Elizabeth A TorroneDivision of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
John R PappDivision of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Robert D KirkcaldyDivision of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Marc LipsitchDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Yonatan H GradDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Centers for Disease Control and Prevention · USBrigham and Women's Hospital · USCenter for Disease Dynamics, Economics & Policy · USHarvard University · US

Funding

Understanding and controlling antibiotic resistanceU54GM088558 · NIGMS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANAGE, WILLIAM · 2009 to 2018
$26.4M
Genomics approaches to elucidating pathways to antibiotic resistance in Neisseria gonorrhoeaeR01AI132606 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Yonatan H Grad · 2017 to 2026
$3.8M
NIAID NIH HHS R01 AI132606NIGMS NIH HHS U54 GM088558
6 · The paper itself

Abstract

Rising azithromycin nonsusceptibility among Neisseria gonorrhoeae isolates threatens current treatment recommendations, but the cause of this rise is not well understood. We performed an ecological study of seasonal patterns in macrolide use and azithromycin resistance in N. gonorrhoeae, finding that population-wide macrolide use is associated with increased azithromycin nonsusceptibility. These results, indicative of bystander selection, have implications for antibiotic prescribing guidelines.

Indexed as

Drug Resistance, BacterialAdolescentAdultAnti-Bacterial AgentsAzithromycinChildDrug UtilizationGonorrheaHumansMacrolidesMiddle AgedNeisseria gonorrhoeaeYoung AdultAnti-Bacterial AgentsAzithromycinMacrolides

Identifiers

PMID30239814
PMCPMC6350947
OpenAlexW2891613987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.