Evidence map›Paper›PMID 30239620›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019

Randomized Controlled Trial of a Mobile Health Intervention to Promote Retention and Adherence to Preexposure Prophylaxis Among Young People at Risk for Human Immunodeficiency Virus: The EPIC Study.

Albert Y Liu, Eric Vittinghoff, Patricia von Felten, K Rivet Amico, Peter L Anderson, Richard Lester, Erin Andrew, Ixchell Estes, Pedro Serrano, Jennifer Brothers and 3 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 98 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02371525 nacompletednot on this map

Enhancing PrEP in Community Settings (EPIC)

TypeinterventionalSponsorUniversity of California, San FranciscoRan2015 to 2017Enrolled121ConditionsHIVArmsPrepmate
NCT05243030 nacompletednot on this mapstarted 2022, after this paper: background citation

Adapting Effective mHealth Interventions to Improve Uptake and Adherence of the HIV Pre-exposure Prophylaxis (PrEP) in Thai Young Men Who Have Sex With Men (MSM).

TypeinterventionalSponsorUniversity of Massachusetts, WorcesterRan2022 to 2025Enrolled119ConditionsPre-Exposure ProphylaxisArmsMotivational Enhancement System for PrEP Uptake and Adherence (MES-PrEP), Motivational Interactive Text Messaging (MTM), Standard PrEP Counseling
3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Albert Y LiuBridge HIV, San Francisco Department of Public Health, University of California, San Francisco.
Eric VittinghoffDepartment of Epidemiology and Biostatistics, University of California, San Francisco.
Patricia von FeltenBridge HIV, San Francisco Department of Public Health, University of California, San Francisco.
K Rivet AmicoDepartment of Health Behavior and Health Education, School of Public Health, University of Michigan, Ann Arbor.
Peter L AndersonSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora.
Richard LesterDivision of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, Canada.
Erin AndrewBridge HIV, San Francisco Department of Public Health, University of California, San Francisco.
Ixchell EstesRuth M. Rothstein CORE Center.
Pedro SerranoRuth M. Rothstein CORE Center.
Jennifer BrothersRuth M. Rothstein CORE Center.
Susan BuchbinderBridge HIV, San Francisco Department of Public Health, University of California, San Francisco.
Sybil HosekRuth M. Rothstein CORE Center.
Jonathan D FuchsDepartment of Medicine, University of California, San Francisco.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 1988 to 2026
$93.6M
Enhancing PrEP in Community Settings (EPIC)R01MH095628 · NIMH · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI LIU, ALBERT YING-HWA · 2011 to 2015
$2.4M
NIAID NIH HHS P30 AI027763NIMH NIH HHS R01 MH095628
6 · The paper itself

Abstract

backgroundYoung men who have sex with men are among the most vulnerable to human immunodeficiency virus (HIV) infection. Although preexposure prophylaxis (PrEP) has demonstrated effectiveness, adherence and retention have been low among youth.

methodsWe conducted a randomized controlled trial to evaluate the impact of a youth-tailored, bidirectional text-messaging intervention (PrEPmate) on study retention and PrEP adherence. Young individuals at risk for HIV initiating PrEP within Chicago's safety-net system were randomized 2:1 to receive PrEPmate or standard of care (SoC) for 36 weeks. The primary retention outcome was study-visit completion, and the primary adherence outcome was tenofovir diphosphate (TFV-DP) concentrations ≥700 fmol/punch (consistent with ≥4 doses/week) assessed at 4, 12, 24, and 36 weeks. The impact of PrEPmate on retention and adherence was evaluated using generalized estimating equation logistic models with robust standard errors.

resultsFrom April 2015 to March 2016, 121 participants enrolled (mean age 24; 27% black, 36% Latino). Participants who received PrEPmate were more likely to attend study visits (86% PrEPmate vs. 71% SoC, odds ratio [OR] = 2.62, 95% confidence interval [CI] 1.24-5.54) and have TFV-DP levels consistent with ≥4 doses/week (72% PrEPmate vs. 57% SoC, OR = 2.05, 95% CI 1.06-3.94). PrEPmate efficacy did not differ significantly by age, race/ethnicity, education, or insurance. Overall, 88% reported PrEPmate to be very/somewhat helpful, and 92% would recommend PrEPmate to others.

conclusionsAn interactive text-messaging intervention had high acceptability and significantly increased study-visit retention and PrEP adherence among young individuals at risk for HIV acquisition. CLINICAL TRIALS REGISTRATION: NCT02371525.

Indexed as

Pre-Exposure ProphylaxisTelemedicineAdolescentAdultAnti-HIV AgentsFemaleHealth Services AccessibilityHIV InfectionsHomosexuality, MaleHumansMaleMedication AdherenceRisk FactorsSexual and Gender MinoritiesSocioeconomic FactorsText MessagingAnti-HIV Agentsadherencemen who have sex with men (MSM)preexposure prophylaxis (PrEP)retentiontext-messaging

Identifiers

PMID30239620
PMCPMC6541706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.