ArticleDiseases of the colon and rectum2018
Secondary Breast, Ovarian, and Uterine Cancers After Colorectal Cancer: A Nationwide Population-Based Cohort Study in Korea.
Article in Diseases of the colon and rectum, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Ovarian metastases from colorectal cancer in young women: a systematic review of the literature.International journal of colorectal disease · 2021Pooled it
- Risk of Gynaecological Cancers as Second Primary in Non-gynaecological Cancer Survivors: A Retrospective Cohort Study.Journal of obstetrics and gynaecology of India · 2025Article
- Perioperative Outcomes of Postmenopausal Women with Colorectal Cancer Undergoing Prophylactic Salpingo-oophorectomy.South Asian journal of cancer · 2025Article
- An unusual presentation of solitary ovarian metastasis from colorectal cancer in an elderly woman: a case report.Journal of gastrointestinal oncology · 2024Article
- Dietary fats and serum lipids in relation to the risk of ovarian cancer: a meta-analysis of observational studies.Frontiers in nutrition · 2023Review
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- Article
- Second primary malignancies in colorectal cancer patients.Scientific reports · 2021Article
- Colonic mucinous adenocarcinoma with secondary in the breast: A case report and literature review.International journal of surgery case reports · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe risk of a second primary cancer has increased along with the increasing life expectancies of colorectal cancer survivors.
objectiveWe aimed to evaluate the incidence rate and risk factors of breast and gynecological (ovarian, uterine cervix/corpus) cancers among female colorectal cancer survivors.
designThis is a retrospective population-based cohort study. SETTINGS: This study used data from the National Health Insurance Corporation of Korea. PATIENTS: Each patient with colorectal cancer diagnosed from 2007 to 2012 was followed until 2015 and compared with age-matched women without colorectal cancer at a 1:5 ratio.
main outcome measuresThe primary outcome was de novo breast/gynecological cancer. Patients with available medical checkup data were included in an additional analysis.
resultsWe analyzed 56,682 patients with colorectal cancer and 288,119 age-matched noncolorectal cancer controls. The risk of breast/gynecological cancer was higher among patients with colorectal cancer than among controls (HR, 2.91; p < 0.001). The association with colorectal cancer was the highest for ovarian cancer (HR, 6.72), followed by uterine corpus cancer (HR, 3.99), cervical cancer (HR, 2.82), and breast cancer (HR, 1.85). This association remained consistent in the subgroup analysis of medical checkup data (14,190 patients with colorectal cancer, 71,933 controls). Among patients with colorectal cancer, those aged <55 years had a higher risk of breast/gynecological cancers than those aged >55 years (HR, 3.51 vs 2.59), and those with dyslipidemia had a higher risk of breast cancer than those without dyslipidemia (HR, 2.66 vs 2.06). LIMITATIONS: This was a retrospective, population-based study. A prospectively designed study is needed to validate our conclusions.
conclusionsCompared with the general population, patients with colorectal cancer carry a higher risk of developing secondary breast, ovarian, and uterine cancers. See Video Abstract at http://links.lww.com/DCR/A731.
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