ReviewCurrent opinion in supportive and palliative care2018
Benzodiazepines for agitation in patients with delirium: selecting the right patient, right time, and right indication.
Review in Current opinion in supportive and palliative care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Trial
- Factors associated with satisfaction with oral sedation during ophthalmic surgeries.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Trial
- Efficacy and Safety of Remimazolam Besylate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial.Drug design, development and therapy · 2022Trial
- Personalized sedation goal for agitated delirium in patients with cancer: Balancing comfort and communication.Cancer · 2021Trial
- Postpartum delirious mania in a patient with diagnosis of bipolar disorder after cesarean delivery: a case report.Frontiers in psychiatry · 2026Article
- Online machine learning model for predicting delirium risk in elderly patients with chronic kidney disease: development and preliminary validation.European journal of medical research · 2025Article
- High prevalence of unrecognized postoperative delirium in elderly patients: a prospective cohort study from a resource-limited country.Patient safety in surgery · 2025Article
- Benzodiazepine-Induced Acute Psychosis Leading to Self-Enucleation and Auto-Cannibalism.Cureus · 2025Article
- Novel and Emerging Treatments for Agitation in Schizophrenia and Bipolar Disorder.Healthcare (Basel, Switzerland) · 2025Review
- Benzodiazepine-receptor agonist prescription in a population of hospitalised patients in four psychogeriatric units in Switzerland.Journal of sleep research · 2025Article
- Association between hospital palliative care team intervention volume and patient outcomes.International journal of clinical oncology · 2024Article
- Delirium in psychiatric settings: risk factors and assessment tools in patients with psychiatric illness: a scoping review.BMC nursing · 2024Article
- Nursing Intervention to Prevent and Manage Delirium in Critically Ill Patients: A Scoping Review.Healthcare (Basel, Switzerland) · 2024Article
- Review
- A-agents, misleadingly known as "Novichoks": a narrative review.Archives of toxicology · 2023Review
- Catatonia in a Patient With Bipolar Affective Disorder and Hypothyroidism: A Diagnostic and Therapeutic Challenge.Cureus · 2023Article
- Management of Physical Symptoms in Patients with Advanced Cancer during the Last Weeks and Days of Life.Cancer research and treatment · 2022Review
- Delirium in Palliative Care.Cancers · 2021Review
- Risk Factors and Antipsychotic Usage Patterns Associated With Terminal Delirium in a Veteran Long-Term Care Hospice Population.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2021Article
- The Management of Psychomotor Agitation Associated with Schizophrenia or Bipolar Disorder: A Brief Review.International journal of environmental research and public health · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewTo provide an evidence-based synopsis on the role of benzodiazepines in patients with agitated delirium. RECENT
findingsExisting evidence supports the use of benzodiazepines in two specific delirium settings: persistent agitation in patients with terminal delirium and delirium tremens. In the setting of terminal delirium, the goal of care is to maximize comfort, recognizing that patients are unlikely to recover from their delirium. A recent randomized trial suggests that lorazepam in combination with haloperidol as rescue medication was more effective than haloperidol alone for the management of persistent restlessness/agitation in patients with terminal delirium. In patients with refractory agitation, benzodiazepines may be administered as scheduled doses or continuous infusion for palliative sedation. Benzodiazepines also have an established role in management of delirium secondary to alcohol withdrawal. Outside of these two care settings, the role of benzodiazepine remains investigational and clinicians should exercise great caution because of the risks of precipitating or worsening delirium and over-sedation. SUMMARY: Benzodiazepines are powerful medications associated with considerable risks and benefits. Clinicians may prescribe benzodiazepines skillfully by selecting the right medication at the right dose for the right indication to the right patient at the right time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.