ArticleActa ophthalmologica2019
Uveitis causes according to immune status of patients.
Article in Acta ophthalmologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Diabetes Mellitus Prevalence by Uveitis Etiology at a Japanese Tertiary Center.Diagnostics (Basel, Switzerland) · 2026Article
- Risk of uveitis in patients with human immunodeficiency virus: a cohort study through TriNetX database.AIDS research and therapy · 2025Article
- Retinal detachment and mortality in patients with cytomegalovirus retinitis: A multicenter study in taiwan.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- A serum B-lymphocyte activation signature is a key distinguishing feature of the immune response in sarcoidosis compared to tuberculosis.Communications biology · 2024Article
- The Wide Spectrum of Presentations of Cytomegalovirus Infection in Immunocompetent Hosts: An Exhaustive Narrative Review.Pathogens (Basel, Switzerland) · 2024Review
- Autoimmune Inflammatory Eye Disease: Demystifying Clinical Presentations for the Internist.Current allergy and asthma reports · 2023Review
- Human Immunodeficiency Virus and Uveitis.Viruses · 2023Review
- Pediatric uveitis: Role of the pediatrician.Frontiers in pediatrics · 2022Review
- Uveitis as an Open Window to Systemic Inflammatory Diseases.Journal of clinical medicine · 2021Article
- Increased incidence of glaucoma medication usage in middle-aged Australian males taking antiretroviral medication - a population-based study.Journal of ophthalmic inflammation and infection · 2020Article
- Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe advances in medicine have led to an increased number of people living with some form of immunodeficiency. Most ocular infections in immunocompromised patients may lead to irreversible blindness. We identify the causes of uveitis in immunocompetent and immunocompromised patients.
methodsA retrospective cohort study of 1354 consecutive patients. All patients underwent a standard work-up for uveitis.
resultsAn immunocompromised state was identified in 171/1354 patients (13%), of whom 40 had Human immunodeficiency virus (HIV) infection, 52 received immunosuppressive medications, 28 had concurrent malignant disorder and 20 had other causes for their immunosuppression. In addition, 93/1354 patients (7%) had diabetes mellitus (DM). The prevalence of intraocular infections was much higher in immunocompromised patients than in immunocompetent patients and DM (p < 0.001). Causes of uveitis differed between the diverse immunocompromised groups. The non-HIV immunocompromised patients showed primarily intraocular herpes simplex and varicella zoster virus infections, whilst HIV-positive patients exhibited frequently cytomegalovirus (CMV) retinitis and syphilis. Patients with generalized malignancies were characterized by a lower prevalence of infections and higher prevalence of sarcoidosis. Patients with DM typically showed sarcoidosis and bacterial intraocular infections. The percentage of undetermined uveitis diagnoses was markedly lower in immunosuppressed patients (p < 0.001).
conclusionIn immunocompromised patients with uveitis, infections were diagnosed in 46% of cases in contrast to 12% in the immunocompetent patients. The causes of uveitis differed among the various types of immunosuppression. Immunocompromised patients with uveitis require a rapid assessment for the most expected infections.
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