ArticleVeterinary and comparative oncology2019
Intra-operative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography.
Article in Veterinary and comparative oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Polarisation-Sensitive Optical Coherence Tomography for Surgical Margin Evaluation and Diagnosis of Excised Canine Cutaneous and Subcutaneous Tumours.Veterinary and comparative oncology · 2026Article
- Biophotonics in veterinary medicine: current clinical applications, translational challenges, and emerging opportunities.Frontiers in veterinary science · 2026Article
- Polarisation Sensitive Optical Coherence Tomography Image Characteristics for Gastrointestinal Tumours and Normal Tissues at Surgical Margins in Dogs.Veterinary and comparative oncology · 2025Article
- Differentiation of canine and feline neoplasms using multi-modal imaging and machine learning.Scientific reports · 2025Article
- Challenges in diagnosing canine spindle cell tumours using immunohistochemistry, illustrated by three nonpigmented malignant cases from the nictitating membrane.Acta veterinaria Scandinavica · 2024Article
- Optical coherence tomography for surgical margin evaluation of excised canine cutaneous and subcutaneous tumours.Veterinary and comparative oncology · 2022Article
- Article
- Diagnostic accuracy of optical coherence tomography for surgical margin assessment of feline injection-site sarcoma.Veterinary and comparative oncology · 2021Article
- Optical coherence tomography imaging of excised canine apocrine gland anal sac adenocarcinoma tumours.Veterinary and comparative oncology · 2021Article
- Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumours.Veterinary and comparative oncology · 2021Article
- The feasibility and utility of optical coherence tomography directed histopathology for surgical margin assessment of canine mast cell tumours.Veterinary and comparative oncology · 2021Article
- Diagnostic accuracy of optical coherence tomography for assessing surgical margins of canine soft tissue sarcomas in observers of different specialties.Veterinary surgery : VS · 2021Article
- Advanced Cancer Imaging Applied in the Comparative Setting.Frontiers in oncology · 2020Article
- Near-infrared imaging and optical coherence tomography for intraoperative visualization of tumors.Veterinary surgery : VS · 2020Review
- Comparison between optical coherence tomographic and histopathologic appearances of artifacts caused by common surgical conditions and instrumentation.Veterinary surgery : VS · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Optical coherence tomography (OCT) is a rapid non-invasive imaging technique that has shown high sensitivity for intra-operative surgical margin assessment in human breast cancer clinical trials. This promising technology has not been evaluated in veterinary medicine. The objective of this study was to correlate normal and abnormal histological features with OCT images for surgical margins from excised canine soft tissue sarcoma (STS) and to establish image evaluation criteria for identifying positive surgical margins. Fourteen client-owned dogs underwent surgical resection of a STS and OCT imaging of 2 to 4 areas of interest on the resected specimen were performed. Following imaging these areas were marked with surgical ink and trimmed for histopathology evaluation. Results showed that different tissue types had distinct characteristic appearances on OCT imaging. Adipose tissue exhibited a relatively low scattering and a honey-comb texture pattern. Skeletal muscle and sarcoma tissue were both dense and highly scattering. While sarcoma tissue was highly scattering, it did not have organized recognizable structure in contrast to muscle which showed clear fibre alignment patterns. In this investigation, we showed different tissue types had different and characteristic scattering and image texture appearances on OCT, which closely correlate with low-power histology images. Given the differentiation between tissue types the results support that OCT could be used to identify positive surgical margins immediately following resection of STS. Further research is needed to assess the diagnostic accuracy of this method for surgical margin assessment.
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