Evidence map›Paper›PMID 30239116›Full record

Trial reportBJU international2019

Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition.

Dennis R Taaffe, Daniel A Galvão, Nigel Spry, David Joseph, Suzanne K Chambers, Robert A Gardiner, Dickon Hayne, Prue Cormie, David H K Shum, Robert U Newton

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BJU international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 11 pooled it
2.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 11 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Effect of exercise on bone-related outcomes in patients with cancer affected by bone metastases or bone loss: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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  6. The effects of exercise on the bone health of people with cancer: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Pooled it
  7. Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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  9. Physical exercise for bone health in men with prostate cancer receiving androgen deprivation therapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  17. UPDATE - Canadian Urological Association guideline on androgen deprivation therapy: Adverse events and management strategies.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Dennis R TaaffeExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.ORCID 0000-0001-6381-1597
Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
Nigel SpryExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
David JosephExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
Suzanne K ChambersExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
Robert A GardinerExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
Dickon HayneUWA Medical School, University of Western Australia, Crawley, Western Australia,, Australia.
Prue CormieMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.
David H K ShumMenzies Health Institute Queensland, Griffith University, Gold Coast, Queensland,, Australia.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.ORCID 0000-0003-0302-6129
Edith Cowan University · AUGriffith University · AUAustralian Catholic University · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo examine whether it is more efficacious to commence exercise medicine in men with prostate cancer at the onset of androgen-deprivation therapy (ADT) rather than later on during treatment to preserve bone and soft-tissue composition, as ADT results in adverse effects including: reduced bone mineral density (BMD), loss of muscle mass, and increased fat mass (FM). PATIENTS AND

methodsIn all, 104 patients with prostate cancer, aged 48-84 years initiating ADT, were randomised to immediate exercise (IMEX, n = 54) or delayed exercise (DEL, n = 50) conditions. The former consisted of 6 months of supervised resistance/aerobic/impact exercise and the latter comprised 6 months of usual care followed by 6 months of the identical exercise programme. Regional and whole body BMD, lean mass (LM), whole body FM and trunk FM, and appendicular skeletal muscle (ASM) were assessed by dual X-ray absorptiometry, and muscle density by peripheral quantitative computed tomography at baseline, and at 6 and 12 months.

resultsThere was a significant time effect (P < 0.001) for whole body, spine and hip BMD with a progressive loss in the IMEX and DEL groups, although lumbar spine BMD was largely preserved in the IMEX group at 6 months compared with the DEL group (-0.4% vs -1.6%). LM, ASM, and muscle density were preserved in the IMEX group at 6 months, declined in the DEL group at 6 months (-1.4% to -2.5%) and then recovered at 12 months after training. FM and trunk FM increased (P < 0.001) over the 12-month period in the IMEX (7.8% and 4.5%, respectively) and DEL groups (6.5% and 4.3%, respectively).

conclusionsCommencing exercise at the onset of ADT preserves lumbar spine BMD, muscle mass, and muscle density. To avoid treatment-related adverse musculoskeletal effects, exercise medicine should be prescribed and commenced at the onset of ADT.

Indexed as

Body CompositionBone DensityAbsorptiometry, PhotonAdipose TissueAgedAged, 80 and overAndrogen AntagonistsAntineoplastic Agents, HormonalExerciseHumansMaleMiddle AgedMuscle, SkeletalProstate-Specific AntigenProstatic NeoplasmsSingle-Blind MethodAndrogen AntagonistsAntineoplastic Agents, HormonalProstate-Specific AntigenTestosteroneandrogen-deprivation therapyexercise#PCSM#ProstateCancer

Identifiers

PMID30239116
PMCPMC6635752
OpenAlexW2780872572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.