ArticleMagnetic resonance in medicine2019
Separating fetal and maternal placenta circulations using multiparametric MRI.
Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 79 citations in OpenAlex.
- Placental Blood-Flow Velocity Quantification From Diffusion MRI.Magnetic resonance in medicine · 2026Article
- Recent innovations in placental MRI: Integrating visualization and functional imaging.Placenta · 2026Review
- A deep learning algorithm for automatic 3D segmentation and classification of the sheep placenta in magnetic resonance images.Physiological reports · 2026Article
- Placental contractions in uncomplicated pregnancies.PloS one · 2026Observational
- Diffusion-T2 correlated spectroscopy imaging to explore possible placental composition changes over gestation.BMC medical imaging · 2025Article
- Quantitative evaluation of placental microvascular blood flow and microstructure in fetal growth restriction with IVIM MRI.Pediatric radiology · 2025Article
- Feasibility of multimodal magnetic resonance imaging to assess maternal hyperoxygenation in sheep pregnancy.The Journal of physiology · 2025Article
- T2*-Relaxometry MRI to Assess Third Trimester Placental and Fetal Brain Oxygenation and Placental Characteristics in Healthy Fetuses and Fetuses With Congenital Heart Disease.Journal of magnetic resonance imaging : JMRI · 2025Article
- Long-Term Neurologic Consequences following Fetal Growth Restriction: The Impact on Brain Reserve.Developmental neuroscience · 2025Review
- In vivo T2 measurements of the fetal brain using single-shot fast spin echo sequences.Magnetic resonance in medicine · 2024Article
- Magnetic resonance imaging of placental intralobule structure and function in a preclinical nonhuman primate model†.Biology of reproduction · 2024Article
- Maternal tadalafil treatment does not increase uterine artery blood flow or oxygen delivery in the pregnant ewe.Experimental physiology · 2024Article
- Advanced magnetic resonance imaging detects altered placental development in pregnancies affected by congenital heart disease.Scientific reports · 2024Article
- Advanced magnetic resonance imaging detects altered placental development in pregnancies affected by congenital heart disease.Research square · 2024Article
- Advanced magnetic resonance imaging in human placenta: insights into fetal growth restriction and congenital heart disease.Frontiers in cardiovascular medicine · 2024Review
- A review of feto-placental vasculature flow modelling.Placenta · 2023Review
- Article
- Assessing within-subject rates of change of placental MRI diffusion metrics in normal pregnancy.Magnetic resonance in medicine · 2023Article
- Developments in functional imaging of the placenta.The British journal of radiology · 2023Review
- Low-Field Combined Diffusion-Relaxation MRI for Mapping Placenta Structure and Function.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeThe placenta is a vital organ for the exchange of oxygen, nutrients, and waste products between fetus and mother. The placenta may suffer from several pathologies, which affect this fetal-maternal exchange, thus the flow properties of the placenta are of interest in determining the course of pregnancy. In this work, we propose a new multiparametric model for placental tissue signal in MRI.
methodsWe describe a method that separates fetal and maternal flow characteristics of the placenta using a 3-compartment model comprising fast and slowly circulating fluid pools, and a tissue pool is fitted to overlapping multiecho T2 relaxometry and diffusion MRI with low b-values. We implemented the combined model and acquisition on a standard 1.5 Tesla clinical system with acquisition taking less than 20 minutes.
resultsWe apply this combined acquisition in 6 control singleton placentas. Mean myometrial T2 relaxation time was 123.63 (±6.71) ms. Mean T2 relaxation time of maternal blood was 202.17 (±92.98) ms. In the placenta, mean T2 relaxation time of the fetal blood component was 144.89 (±54.42) ms. Mean ratio of maternal to fetal blood volume was 1.16 (±0.6), and mean fetal blood saturation was 72.93 (±20.11)% across all 6 cases.
conclusionThe novel acquisition in this work allows the measurement of histologically relevant physical parameters, such as the relative proportions of vascular spaces. In the placenta, this may help us to better understand the physiological properties of the tissue in disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.