ArticleArtificial organs2018
Biocompatibility of Polysulfone Hemodialysis Membranes and Its Mechanisms: Involvement of Fibrinogen and Its Integrin Receptors in Activation of Platelets and Neutrophils.
Article in Artificial organs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 85 citations in OpenAlex.
- Vitamin e-loaded membrane dialyzers reduce hemodialysis inflammaging.BMC nephrology · 2019Trial
- Correlation between real sieving coefficient determined using novel lab-scale module and pore structure of hemodiafiltration membranes.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Article
- An In Vitro System for Studying Toxin Transport Across Hemodialysis Membranes.Artificial organs · 2026Article
- Exploratory study of dialysis membrane impact on epigenetic methylation patterns in hemodialysis patients using genomic and synchrotron investigations.Scientific reports · 2026Article
- Personalized Hemodialysis Approaches in Frail Older Individuals.Geriatrics (Basel, Switzerland) · 2026Review
- Comparison of the biocompatibility profiles of synthetic polysulfone and polyethersulfone dialysis membranes.Clinical kidney journal · 2026Article
- In Vitro Thrombogenicity Evaluation of Hemodialyzers.International journal of molecular sciences · 2026Article
- Dialyzer characteristics are associated with differential effects on intradialytic microvascular tissue perfusion.Annals of medicine and surgery (2012) · 2026Article
- Knockout of p47phox inhibits deep vein thrombosis by regulating the PAC-1/FNG/MAC-1 signaling axis and ameliorating mitochondrial dysfunction.Frontiers in immunology · 2026Article
- Biocompatibility in hemodialysis: artificial membrane and human blood interactions.BMC nephrology · 2025Review
- In Vitro Evaluation of Liposomal Amphotericin B Adsorption With Different Hemofilters for Continuous Hemofiltration.Artificial organs · 2025Article
- Superior forward osmosis cellulosic membrane for water desalination and brine concentration.Scientific reports · 2025Article
- Development and Investigation of a New Polysulfone Dialyzer with Increased Membrane Hydrophilicity.Membranes · 2025Review
- Effects of Diet and Supplements on Parameters of Oxidative Stress, Inflammation, and Antioxidant Mechanisms in Patients with Chronic Renal Failure Undergoing Hemodialysis.International journal of molecular sciences · 2024Article
- Flexible inner surface of polysulfone membranes prevents platelet adhesive protein adsorption and improves antithrombogenicity in vitro.The International journal of artificial organs · 2024Article
- The Complex Immunological Alterations in Patients with Type 2 Diabetes Mellitus on Hemodialysis.Journal of clinical medicine · 2024Review
- Hemostatic capability of ultrafiltrated fresh frozen plasma compared to cryoprecipitate.Scientific reports · 2023Article
- Platelet thrombus formation in patients with end-stage renal disease before and after hemodialysis as measured by the total thrombus-formation analysis system.International urology and nephrology · 2022Article
- Impact of Hydrophilic Modification of Synthetic Dialysis Membranes on Hemocompatibility and Performance.Membranes · 2022Review
- Immune System Dysfunction and Inflammation in Hemodialysis Patients: Two Sides of the Same Coin.Journal of clinical medicine · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of blood cells during hemodialysis is considered to be a significant determinant of biocompatibility of the hemodialysis membrane because it may affect patient health adversely through microvascular inflammation and oxidative stress. This study found very different cell activation among various polysulfone (PSf) hemodialysis membranes. For example, CX-U, a conventional PSf membrane, induced marked adhesion of platelets to its surface and increased surface expression of activated CD11b and production of reactive oxygen species (ROS) by neutrophils; while NV-U, a hydrophilic polymer-immobilized PSf membrane, caused little platelet adhesion and slight CD11b expression and ROS production by neutrophils. Analysis of the molecular mechanisms of the above phenomena on CX-U and NV-U indicated that anti-integrin GPIIb/IIIa antibody blocked platelet adhesion, and that the combination of anti-CD11b (integrin α subunit of Mac-1) and anti-integrin αvβ3 antibodies blocked ROS production by neutrophils. Plasma-derived fibrinogen, a major ligand of GPIIb/IIIa, Mac-1, and αvβ3 on membranes, was thus analyzed and found to be more adsorbed to CX-U than to NV-U. Moreover, comparison between five PSf membranes showed that the number of adherent platelets and neutrophil ROS production increased with increasing fibrinogen adsorption. These results suggested that fibrinogen, adsorbed on membranes, induced GPIIb/IIIa-mediated platelet activation and Mac-1/αvβ3-mediated neutrophil activation, depending on the amount of adsorption. In conclusion, the use of biocompatible membranes like NV-U, which show lower adsorption of fibrinogen, is expected to reduce hemodialysis-induced inflammation and oxidative stress by minimizing cell activation.
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