ArticleEpigenomics2018
Allele-specific methylation of imprinted genes in fetal cord blood is influenced by cis-acting genetic variants and parental factors.
Article in Epigenomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Pooled it
- rDNA Copy Number Variation and Methylation in Human and Mouse Sperm.International journal of molecular sciences · 2025Article
- Examining the epigenetic transmission of risk for chronic pain associated with paternal post-traumatic stress disorder: a focus on veteran populations.Translational psychiatry · 2025Review
- Review
- Age-related and species-specific methylation changes in the protein-coding marmoset sperm epigenome.Aging cell · 2024Article
- Effects of paternal and chronological age onAging · 2023Article
- Article
- The methylation profile ofFrontiers in immunology · 2023Article
- Epigenetic Risks of Medically Assisted Reproduction.Journal of clinical medicine · 2022Review
- Species-Specific Paternal Age Effects and Sperm Methylation Levels of Developmentally Important Genes.Cells · 2022Article
- Article
- Article
- A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity.Scientific reports · 2021Article
- Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline.Aging cell · 2020Article
- Assisted reproductive technology represents a possible risk factor for development of epimutation-mediated imprinting disorders for mothers aged ≥ 30 years.Clinical epigenetics · 2020Article
- DNA Methylation Biomarkers in Aging and Age-Related Diseases.Frontiers in genetics · 2020Review
- Unbalanced segregation of a paternal t(9;11)(p24.3;p15.4) translocation causing familial Beckwith-Wiedemann syndrome: a case report.BMC medical genomics · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine the effects of genetic variation, parental age and BMI on parental allele-specific methylation of imprinted genes in fetal cord blood samples. METHODOLOGY: We have developed SNP genotyping and deep bisulphite sequencing assays for six imprinted genes to determine parental allele-specific methylation patterns in diploid somatic tissues.
resultsMultivariate linear regression analyses revealed a negative correlation of paternal age with paternal MEG3 allele methylation in fetal cord blood. Methylation of the maternal PEG3 allele showed a positive correlation with maternal age. Paternal BMI was positively correlated with paternal MEST allele methylation. In addition to parental origin, allele-specific methylation of most imprinted genes was largely dependent on the underlying SNP haplotype.
conclusionOur study supports the idea that parental factors can have an impact, although of small effect size, on the epigenome of the next generation, providing an additional layer of complexity to phenotypic diversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.