Observational studyArthritis care & research2019
Physical Activity and Worsening of Radiographic Findings in Persons With or at Higher Risk of Knee Osteoarthritis.
Observational study in Arthritis care & research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Temporal Patterns of Wearable Accelerometer-Measured Physical Activity and Symptom Worsening in Knee Osteoarthritis: A 2-Year Longitudinal Study from the Osteoarthritis Initiative.Sensors (Basel, Switzerland) · 2026Article
- Investigating the association between knee osteoarthritis symptoms with pain catastrophizing domains between Hispanics and non-Hispanic Whites.Rheumatology international · 2024Article
- Association of physical activity with loss of knee joint space width over two years: a compositional data analysis in the Osteoarthritis Initiative.Osteoarthritis and cartilage · 2023Article
- Longitudinal Relationship Between Physical Activity and Joint Space Narrowing: Forty-Eight-Month Follow-Up Data From the Osteoarthritis Initiative.Arthritis care & research · 2022Article
- Linking physical activity with clinical, functional, and structural outcomes: an evidence map using the Osteoarthritis Initiative.Clinical rheumatology · 2022Review
- Knee joint unloading and daily physical activity associate with cartilage T2 relaxation times 1 month after ACL injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Factors associated with pain resolution in those with knee pain: the MOST study.Osteoarthritis and cartilage · 2021Article
- Nonsurgical Management of Cartilage Defects of the Knee: Who, When, Why, and How?The journal of knee surgery · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveThe benefits of physical activity among persons with or at higher risk for knee osteoarthritis are well established. However, activity levels in this population are low, in part due to concern that activity will damage the knee joint. We hypothesized that sedentary and moderate-vigorous physical activity are each associated with greater risk of radiographic worsening of knee OA.
methodsIn Osteoarthritis Initiative participants with or at higher risk for knee OA enrolled in an accelerometer substudy at 48 months (study baseline), physical activity was measured by a uniaxial accelerometer (ActiGraph GT1M). Radiographic progression was defined as any 48 month to 96 month worsening of Kellgren/Lawrence (K/L) grade scores. All analyses were knee-level; we used multivariable logistic regression with generalized estimating equations, adjusting for key covariates.
resultsOf the 1,206 participants, 631 (52%) were female, the mean ± SD age was 64 ± 9 years, and mean ± SD body mass index (BMI) was 28 ± 5. The mean ± SD average daily sedentary activity was 602 ± 86 minutes, average daily light activity was 284 ± 75 minutes, and average daily moderate-vigorous activity was 20 ± 20 minutes. In 1,978 knees, 267 (14%) had worsening of K/L grade scores. In the multivariable model, age, sex, BMI, and pain, were associated with K/L grade worsening, but neither sedentary activity (adjusted odds ratio [OR] 0.99 [95% confidence interval (95% CI) 0.97-1.01]) nor moderate-vigorous activity (adjusted OR 1.00 [95% CI 0.91-1.09]) were associated with K/L grade worsening.
conclusionIn persons with or at higher risk for knee OA, age, sex, BMI, and pain, but not objectively measured average daily minutes of sedentary or moderate-vigorous activity, were associated with subsequent worsening of K/L grade. Whether findings differ in persons with more severe knee OA and/or engaged more frequently in moderate-vigorous activity should be examined in future studies.
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