ArticleMolecular and cellular biology1986
Two modes of c-myb activation in virus-induced mouse myeloid tumors.
Article in Molecular and cellular biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 135 citations in OpenAlex.
- Reversal of MYB-dependent suppression of MAFB expression overrides leukaemia phenotype in MLL-rearranged AML.Cell death & disease · 2023Article
- Myb expression is critical for myeloid leukemia development induced by Setbp1 activation.Oncotarget · 2016Article
- Review
- An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.Genes & development · 2011Article
- The chicken miR-150 targets the avian orthologue of the functional zebrafish MYB 3'UTR target site.BMC molecular biology · 2010Article
- Insertional gene activation by lentiviral and gammaretroviral vectors.Journal of virology · 2009Article
- Functional genomic analysis reveals distinct neoplastic phenotypes associated with c-myb mutation in the bursa of Fabricius.Oncogene · 2003Article
- Review
- A novel subgenomic murine leukemia virus RNA transcript results from alternative splicing.Journal of virology · 2000Article
- Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis.Molecular and cellular biology · 2000Article
- Sint1, a common integration site in SL3-3-induced T-cell lymphomas, harbors a putative proto-oncogene with homology to the septin gene family.Journal of virology · 2000Article
- Review
- FAETL motif required for leukemic transformation by v-Myb.Journal of virology · 1996Article
- Casein kinase II phosphorylation site mutations in c-Myb affect DNA binding and transcriptional cooperativity with NF-M.Molecular and cellular biology · 1995Article
- Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Novel integration sites at the distal 3' end of the c-myb locus in retrovirus-induced promonocytic leukemias.Journal of virology · 1995Article
- The carboxyterminus of human c-myb protein stimulates activated transcription in trans.Nucleic acids research · 1994Article
- Recognition of specific DNA sequences by the c-myb protooncogene product: role of three repeat units in the DNA-binding domain.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Characterization of unintegrated retroviral DNA with long terminal repeat-associated cell-derived inserts.Journal of virology · 1992Article
- New sites of proviral integration associated with murine promonocytic leukemias and evidence for alternate modes of c-myb activation.Journal of virology · 1992Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two modes of disruption of the protooncogene c-myb by viral insertional mutagenesis in mouse myeloid tumor cells are described. The first mode was found in six tumors in which a Moloney murine leukemia virus component had inserted in the same transcriptional orientation upstream of the 5'-most exon with v-myb homology (vE1). cDNA sequence data indicate the presence of a truncated c-myb mRNA that is initiated in the upstream 5' long terminal repeat of the integrated provirus and processed via a cryptic splice donor sequence in the gag region to the splice acceptor site in vE1 of the c-myb gene, thus removing the remaining downstream viral and myb intronic sequences. Unlike most gag-onc transcripts, the gag and myb sequences in the hybrid transcript were not in the same reading frame. It is presumed that the gag sequence provides a cryptic translation initiation site for the novel amino-truncated c-myb protein. The second mode of disruption was by downstream virus insertion at the 3' side of the c-myb, which results in the synthesis of a small (approximately 2 kilobase) myb transcript. The 5' long terminal repeat of the inserted provirus provides a TGA termination codon that results in the elimination of 240 normal c-myb amino acid residues from the carboxyl terminus of the tumor-specific myb protein. These results suggest that truncated myb proteins play a role in neoplastic transformation of myeloid cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.