SynthesisClinical oral investigations2019
MTA and biodentine for primary teeth pulpotomy: a systematic review and meta-analysis of clinical trials.
Synthesis in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06398327 (Efficacy Of Proinflammatory Cytokines in the Clinical And Radiographic Outcomes of Different Primary Molar Pulpotomy Agents), which is not on this map. Cited by 40 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy Of Proinflammatory Cytokines in the Clinical And Radiographic Outcomes of Different Primary Molar Pulpotomy Agents: A Comparative Study Featuring A Novel Biomarker For Pulpal Diagnosis
Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Efficacy and safety of diode laser in pulpotomy: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Mapping Systematic Reviews on the Management of Dental Caries in Primary Teeth: A Meta-research.Current pediatric reviews · 2026Pooled it
- 3Mixtatin versus MTA in pulp therapy of primary teeth: a systematic review and meta-analysis of current randomized controlled trials.Evidence-based dentistry · 2024Pooled it
- Retrograde filling material in periapical surgery: a systematic review.Medicina oral, patologia oral y cirugia bucal · 2021Pooled it
- Materials for pulpotomy in immature permanent teeth: a systematic review and meta-analysis.BMC oral health · 2019Pooled it
- Trial
- Long-term evaluation of primary teeth molar pulpotomies with Biodentine and MTA: a CONSORT randomized clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Trial
- A randomised controlled clinical trial comparing pure Portland cement and formocresol pulpotomies followed from 2 to 4 years.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Trial
- Tailored 70S30C Bioactive glass induces severe inflammation as pulpotomy agent in primary teeth: an interim analysis of a randomised controlled trial.Clinical oral investigations · 2021Trial
- Clinical and Radiographic Outcomes of Calcium-Silicate-Based Materials in Primary-Tooth Pulpotomy: An Umbrella Review.Journal of clinical medicine · 2026Review
- Comparative evaluation of iRoot BP Plus and mineral trioxide aggregate for pulpotomy in primary molars with reversible pulpitis under intraoral endoscope: a retrospective study.BMC oral health · 2026Article
- Success of pulpotomy with MTA in primary teeth: A systematic review and meta-analysis.Bioinformation · 2025Article
- Rescuing a "hopeless" tooth with severe internal resorption during orthodontic therapy: a case report.Frontiers in oral health · 2025Article
- Pulpotomy in primary teeth: Biodentine™ versus calcium hydroxide. A systematic review and meta-analysis.The Saudi dental journal · 2024Review
- A retrospective study on the outcome of pulpotomy with iRoot BP plus in primary molars and its relationship with hemostasis time.BMC oral health · 2024Article
- Calcium Silicate-Based Cements in Restorative Dentistry: Vital Pulp Therapy Clinical, Radiographic, and Histological Outcomes on Deciduous and Permanent Dentition-A Systematic Review and Meta-Analysis.Materials (Basel, Switzerland) · 2024Review
- Hard tissue formation in pulpotomized primary teeth in dogs with nanomaterials MCM-48 and MCM-48/hydroxyapatite: an in vivo animal study.BMC oral health · 2024Article
- Evaluation of Cytotoxicity ofInternational journal of clinical pediatric dentistry · 2024Article
- Outcome of novel pulp capping modalities after full pulpotomy in teeth diagnosed with irreversible pulpitis: A prospective randomized clinical trial.Journal of conservative dentistry and endodontics · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to perform a systematic review and meta-analysis of clinical trials in order to evaluate the clinical and radiographic success rates of primary teeth pulpotomy performed with biodentine, when compared to MTA.
methodsSearch strategies were conducted in nine databases on August 5th, 2017, update on February 14th, 2018. Clinical articles were selected, which were in accordance with the inclusion and exclusion criteria and the research objective. They were analyzed by meta-analysis at three time points (6, 12, and 18 months).
resultsOut of the 233 publications initially identified, only 9 studies that fulfilled the inclusion criteria were included in the review. The 6-month overall clinical (RR = 0.99; 95% CI = 0.96-1.02, p = 0.92) and radiographic success rates (RR = 0.96; 95% CI = 0.92-1.00, p = 0.28) showed that biodentine vs. MTA did not differ statistically. The 12 and 18-month overall clinical success rates, respectively (RR = 1.01; 95% CI = 0.97-1.04, p = 0.77; RR = 0.98; 95% CI = 0.92-1.05, p = 0.74) and radiographic success rates, respectively (RR = 0.97; 95% CI = 0.92-1.02, p = 0.11; RR = 1.00; 95% CI = 0.91-1.10, p = 0.56) also showed that biodentine vs. MTA did not differ statistically.
conclusionThere is no superiority of one material over the other, MTA versus biodentine. CLINICAL RELEVANCE: This systematic review comparing the performance of biodentine in relation to the MTA when used in the pulpotomy technique in primary teeth. Although MTA is considered the gold standard material for pulpotomy procedures, it has some drawbacks (poor handling, staining potential, long setting time); thus, it is important to evaluate the clinical performance of other calcium silicate-based cements like biodentine that overcome this drawbacks.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.