Evidence map›Paper›PMID 30238404›Full record

ArticleJournal of general internal medicine2019

Race and Hepatitis C Care Continuum in an Underserved Birth Cohort.

Nicole J Kim, Cameron J Locke, Helen Park, Catherine Magee, Peter Bacchetti, Mandana Khalili

Open access · bronzeAbstract read
In one paragraph

Article in Journal of general internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Racial and Ethnic Disparities in Hepatitis C Care in Reproductive-Aged Women With Opioid Use Disorder.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Hepatitis C Cascades: Data to Inform Hepatitis C Elimination in the United States.Public health reports (Washington, D.C. : 1974) · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Inflammatory bowel disease type influences development of elevated liver enzymes.JGH open : an open access journal of gastroenterology and hepatology · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicole J KimDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Cameron J LockeDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Helen ParkDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Catherine MageeDepartment of Medicine, Division of Gastroenterology and Hepatology, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA.
Peter BacchettiDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Mandana KhaliliDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA. Mandana.Khalili@ucsf.edu.
San Francisco General Hospital · USUniversity of California, San Francisco · US

Funding

Mentoring Multidisciplinary Patient-Oriented Research in Viral HepatitisK24AA022523 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHALILI, MANDANA · 2013 to 2023
$1.9M
NIAAA NIH HHS K24 AA022523
6 · The paper itself

Abstract

backgroundBirth cohort screening is recommended for hepatitis C virus (HCV) and underserved populations are disproportionally affected by HCV. Little is known about the influence of race on the HCV care continuum in this population.

objectiveTo assess the cascade of HCV care in a large racially diverse and underserved birth cohort.

designRetrospective cohort study using electronic medical record data abstracted until August 31, 2017. PATIENTS: 34,810 patients born between 1945 and 1965 engaged in primary care between October 1, 2014, and October 31, 2016, within the safety-net clinics of the San Francisco Health Network. MAIN MEASURES: Rate of hepatitis C testing, hepatitis C treatment, and response to therapy.

resultsCohort characteristics were as follows: median age 59 years, 57.6% male, 25.5% White (20.6% Black, 17.7% Latino, 33.0% Asian/Pacific Islander (API), 2% other), and 32.6% preferred a non-English language. 99.7% had an HCV test (95.4% HCV antibody, 4.3% HCVRNA alone). Among HCV antibody-positive patients (N = 4587), 22.9% were not tested for confirmatory HCVRNA. Among viremic patients (N = 3673), 20.8% initiated HCV therapy, 90.6% achieved sustained virologic response (SVR) and 8.1% did not have a SVR test. HCV screening and treatment were highest in APIs (98.7 and 34.7% respectively; p < 0.001). Blacks had the highest chronic HCV rate (22.2%; p < 0.001). Latinos had the lowest SVR rate (81.3%; p = 0.01). On multivariable analysis, API race (vs White, OR 1.20; p = 0.001), presence of HIV co-infection (OR 1.58; p = 0.02), presence of chronic kidney disease (OR 0.47; p < 0.001), English (vs non-English) as preferred language (OR 0.54; p = 0.002), ALT (OR 0.39 per doubling; p < 0.001), and HCVRNA (OR 0.83 per 10-fold increase; p < 0.001) were associated with HCV treatment.

conclusionsDespite near-universal screening, gaps in active HCV confirmation, treatment, and verification of cure were identified and influenced by race. Tailored interventions to engage and treat diverse and underserved populations with HCV infection are needed.

Indexed as

Antiviral AgentsBlack or African AmericanContinuity of Patient CareDiagnostic Tests, RoutineDrug UtilizationElectronic Health RecordsFemaleHepacivirusHepatitis C, ChronicHumansMaleMass ScreeningMiddle AgedPrimary Health CareRetrospective StudiesSan FranciscoAntiviral AgentsAfrican Americandirect-acting antiviralshealth disparitylinkage to carevulnerable populations

Identifiers

PMID30238404
PMCPMC6816604
OpenAlexW2890038704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.