Evidence map›Paper›PMID 30238401›Full record

GuidelineWorld journal of urology2019

SIU-ICUD recommendations on bladder cancer: systemic therapy for metastatic bladder cancer.

Axel S Merseburger, Andrea B Apolo, Simon Chowdhury, Noah M Hahn, Matthew D Galsky, Matthew I Milowsky, Daniel Petrylak, Tom Powles, David I Quinn, Jonathan E Rosenberg and 3 more

Open access · greenAbstract readPractice GuidelineReview
In one paragraph

Guideline in World journal of urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Patients with Bladder Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 4 countries.

Axel S MerseburgerDepartment of Urology, Campus Lübeck, University Hospital Schleswig-Holstein, Lübeck, Germany.
Andrea B ApoloCenter for Cancer Research, National Cancer Institute, NIH Maryland, Bethesda, USA.
Simon ChowdhuryGuy's and St, Thomas' Hospital, Great Maze Pond, London, UK.
Noah M HahnSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA.
Matthew D GalskyDivision of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Matthew I MilowskyDivision of Hematology/Oncology, Department of Medicine, University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.
Daniel PetrylakYale Cancer Center, New Haven, CT, USA.
Tom PowlesBarts Cancer Institute, London, USA.
David I QuinnNorris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Jonathan E RosenbergMemorial Sloan Kettering Cancer Center, New York, USA.
Arlene Siefker-RadtkeDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Guru SonpavdeDepartment of Medical Oncology, Bladder Cancer Center, Dana Farber Cancer Institute, Boston, MA, USA.
Cora N SternbergDepartment of Medical Oncology, San Camillo Forlanini Hospital, Rome, Italy. cnsternberg@corasternberg.com.
Carlo Forlanini Hospital · ITDana-Farber Cancer Institute · USIcahn School of Medicine at Mount Sinai · USMemorial Sloan Kettering Cancer Center · USNational Cancer Institute · USSidney Kimmel Comprehensive Cancer Center · USSt Thomas' Hospital · GBThe University of Texas MD Anderson Cancer Center · USUniversity of Lübeck · DEUniversity of North Carolina at Chapel Hill · USUniversity of Southern California · USYale Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Bladder Cancer ProgramZIABC011351 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APOLO, ANDREA · 2010 to 2025
$9.4M
NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

The SIU (Société Internationale d'Urologie)-ICUD (International Consultation on Urologic Diseases) working group on systemic therapy for metastatic bladder cancer has summarized the most recent findings on the aforementioned topic and came to conclusions and recommendations according to the evidence published. In Europe and the United States, treatment for metastatic UC has changed a great deal recently, mainly involving a move from chemotherapy to immune checkpoint blockers. This is particularly true in platinum-refractory disease, where supportive randomized data exist. Five checkpoint blockers have been approved in this setting by the FDA: avelumab, atezolizumab, durvalumab, nivolumab, and pembrolizumab. Nivolumab, pembrolizumab, and atezolizumab have been approved in Europe.

Indexed as

Antibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic Agents, ImmunologicalAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCarcinoma, Transitional CellCisplatinDeoxycytidineDoxorubicinGemcitabineHumansLiver NeoplasmsMethotrexateNivolumabPaclitaxelUrinary Bladder NeoplasmsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic Agents, ImmunologicalatezolizumabavelumabCarboplatinCisplatinDeoxycytidineDoxorubicindurvalumabGemcitabineMethotrexateNivolumabPaclitaxelpembrolizumabVinblastineBladder cancerCheckpoint inhibitorsChemotherapy immunotherapyUrothelial cancer

Identifiers

PMID30238401
PMCPMC7515768
OpenAlexW2889605632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.