Evidence map›Paper›PMID 30238327›Full record

ArticleEndocrine2019

Surgical outcomes and predictors of glucose metabolism alterations for growth hormone-secreting pituitary adenomas: a hospital-based study of 151 cases.

Wenqiang He, Linling Yan, Meng Wang, Qin Li, Min He, Zengyi Ma, Zhao Ye, Qilin Zhang, Yichao Zhang, Nidan Qiao and 10 more

Abstract read
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In one paragraph

Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Wenqiang HeDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Linling YanDepartment of Endocrinology, the First People's Hospital of Taicang, Jiangsu, 215400, China.
Meng WangDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Qin LiDepartment of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University, Shanghai, 200011, China.
Min HeDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zengyi MaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhao YeDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Qilin ZhangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yichao ZhangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Nidan QiaoDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yun LuDepartment of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Hongying YeDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Bin LuDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xuefei ShouDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yao ZhaoDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yiming LiDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Shiqi LiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhaoyun ZhangDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Ming ShenDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. samshenming@yahoo.com.ORCID http://orcid.org/0000-0002-1968-3177
Yongfei WangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. eamns@hotmail.com.
Fudan University · CNShanghai Jiao Tong University · CNTaizhou First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe surgical outcome on glucose metabolism in acromegaly patients is not fully understood. We aimed to investigate the impact of surgery on glucose metabolism and identify key factors that influence alterations of glucose metabolic status in acromegaly patients.

methodsOral glucose tolerance test was performed in 151 newly diagnosed acromegaly patients before and 3-12 months after surgery. Insulin resistance and insulin secretion was assessed. Patients were grouped as cured, discordant, and having active disease according to postoperative growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels. Receiver-operating characteristic curves were generated to determine the optimal cut-off points to predict the impact of surgery on glucose metabolism.

resultsAt baseline, 32.5%, 41.7%, and 25.8% patients were categorized as having normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and diabetes mellitus (DM), respectively. After surgery, improved glucose tolerance was observed in 87.3% patients with IGT and 66.7% patients with DM. Deterioration was observed in 14.3% patients with NGT. Glucose tolerance improved in patients with lower preoperative FBG, 2 h-BG, and HbA1c and higher HOMA-β and IGI/IR. The proportion of NGT was significantly increased in surgically cured patients (28.3% vs. 79.2%, P < 0.001) and those with normal GH but elevated IGF-1 levels (25.6% vs. 79.5%, P < 0.001), but not in patients with active disease (42.9% vs. 57.1%, P = 0.131). Baseline FBG < 6.35 mmol/l predicted improved glucose metabolism after surgery.

conclusionsGlucose metabolic status improved in patients with preserved β-cell function. Preoperative FBG was an independent predictor for improved glucose tolerance status after surgery.

Indexed as

AcromegalyAdenomaAdultDiabetes ComplicationsFemaleGlucoseGlucose Tolerance TestGrowth Hormone-Secreting Pituitary AdenomaHuman Growth HormoneHumansInsulinInsulin-Like Growth Factor IInsulin ResistanceMaleMiddle AgedReference ValuesGlucoseHuman Growth HormoneInsulinInsulin-Like Growth Factor IAcromegalyGlucose homeostasisGlucose metabolism disordersInsulin resistanceSurgery

Identifiers

PMID30238327
OpenAlexW2890782525

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.