Evidence map›Paper›PMID 30238243›Full record

ArticleAnnals of surgical oncology2019

The Impact of Education and Prescribing Guidelines on Opioid Prescribing for Breast and Melanoma Procedures.

Jay S Lee, Ryan A Howard, Michael P Klueh, Michael J Englesbe, Jennifer F Waljee, Chad M Brummett, Michael S Sabel, Lesly A Dossett

Abstract read
In one paragraph

Article in Annals of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 70 citations in OpenAlex.

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  11. How to teach ERAS protocols: surgical residents' perspectives and perioperative practices for breast surgery patients.Global surgical education : journal of the Association for Surgical Education · 2023
    Article
  12. Reducing Opioid Overprescribing through Procedure-specific Prescribing Guidelines.Plastic and reconstructive surgery. Global open · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jay S LeeDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.
Ryan A HowardDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.
Michael P KluehDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.
Michael J EnglesbeDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.
Jennifer F WaljeeDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.
Chad M BrummettDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Michael S SabelDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.
Lesly A DossettDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA. ldossett@med.umich.edu.
University of Michigan–Ann Arbor · USMichigan Center for Translational Pathology · US

Funding

University of Michigan Surgical Oncology Research Training ProgramT32CA009672 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACQUELINE SARA JERUSS, WEIPING ZOU · 1991 to 2026
$6.0M
oPIOIDS: Prevention of Iatrogenic Opioid Dependence after SurgeryR01DA042859 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRUMMETT, CHAD M, WALJEE, JENNIFER FILIP · 2017 to 2021
$3.6M
National Cancer Institute 5T32 CA009672-23National Institute on Drug Abuse RO1 DA042859NCI NIH HHS T32 CA009672NIDA NIH HHS R01 DA042859
6 · The paper itself

Abstract

backgroundExcessive opioid prescribing is common in surgical oncology, with 72% of prescribed opioids going unused after curative-intent surgery. In this study, we sought to reduce opioid prescribing after breast and melanoma procedures by designing and implementing an intervention focused on education and prescribing guidelines, and then evaluating the impact of this intervention.

methodsIn this single-institution study, we designed and implemented an intervention targeting key factors identified in qualitative interviews. This included mandatory education for prescribers, evidence-based prescribing guidelines, and standardized patient instructions. After the intervention, interrupted time-series analysis was used to compare the mean quantity of opioid prescribed before and after the intervention (July 2016-September 2017). We also evaluated the frequency of opioid prescription refills.

resultsDuring the study, 847 patients underwent breast or melanoma procedures and received an opioid prescription. For mastectomy or wide local excision for melanoma, the mean quantity of opioid prescribed immediately decreased by 37% after the intervention (p = 0.03), equivalent to 13 tablets of oxycodone 5 mg. For lumpectomy or breast biopsy, the mean quantity of opioid prescribed decreased by 42%, or 12 tablets of oxycodone 5 mg (p = 0.07). Furthermore, opioid prescription refills did not significantly change for mastectomy/wide local excision (13% vs. 14%, p = 0.8), or lumpectomy/breast biopsy (4% vs. 5%, p = 0.7).

conclusionEducation and prescribing guidelines reduced opioid prescribing for breast and melanoma procedures without increasing the need for refills. This suggests further reductions in opioid prescribing may be possible, and provides rationale for implementing similar interventions for other procedures and practice settings.

Indexed as

Analgesics, OpioidBreast NeoplasmsCohort StudiesDrug PrescriptionsFemaleFollow-Up StudiesHumansInappropriate PrescribingMastectomyMelanomaOncologistsPostoperative PainPractice Guidelines as TopicPractice Patterns, Physicians'PrognosisAnalgesics, Opioid

Identifiers

PMID30238243
PMCPMC6339586
OpenAlexW2892305309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.