ArticleMolecular and cellular biology1986
The complete sequence of the mouse skeletal alpha-actin gene reveals several conserved and inverted repeat sequences outside of the protein-coding region.
Article in Molecular and cellular biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 96 citations in OpenAlex.
- DNA methylation profile of the mouse skeletal alpha-actin promoter during development and differentiation.Molecular and cellular biology · 1999Article
- Tissue-restricted expression of the cardiac alpha-myosin heavy chain gene is controlled by a downstream repressor element containing a palindrome of two ets-binding sites.Molecular and cellular biology · 1998Article
- An alternative promoter in the mouse major histocompatibility complex class II I-Abeta gene: implications for the origin of CpG islands.Molecular and cellular biology · 1998Article
- Neurogenic potential of Ewing's sarcoma cells.Virchows Archiv : an international journal of pathology · 1997Article
- Further examples of evolution by gene duplication revealed through DNA sequence comparisons.Genetics · 1994Article
- Electrical activity-dependent regulation of the acetylcholine receptor delta-subunit gene, MyoD, and myogenin in primary myotubes.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Linkage of Agt and Actsk-1 to distal mouse chromosome 8 loci: a new conserved linkage.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Re-localization of Actsk-1 to mouse chromosome 8, a new region of homology with human chromosome 1.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Article
- Identification of single-stranded-DNA-binding proteins that interact with muscle gene elements.Molecular and cellular biology · 1991Article
- Adrenergic regulation of the skeletal alpha-actin gene promoter during myocardial cell hypertrophy.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Common factor 1 is a transcriptional activator which binds in the c-myc promoter, the skeletal alpha-actin promoter, and the immunoglobulin heavy-chain enhancer.Molecular and cellular biology · 1991Article
- Colony-stimulating factor 1 expression is down-regulated during the adipocyte differentiation of H-1/A marrow stromal cells and induced by cachectin/tumor necrosis factor.Molecular and cellular biology · 1991Article
- Structure and expression of a single actin gene in Volvox carteri.Current genetics · 1990Article
- T-cell specific rearrangement of T-cell receptor beta transgenes in mice.The EMBO journal · 1990Article
- Effect of thyroid hormone on the accumulation of mRNA for skeletal and cardiac alpha-actin in hearts from normal and hypophysectomized rats.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene.Molecular and cellular biology · 1990Article
- The cyclic nucleotide phosphodiesterase gene of Dictyostelium discoideum utilizes alternate promoters and splicing for the synthesis of multiple mRNAs.Molecular and cellular biology · 1989Article
- The chicken skeletal muscle alpha-actin promoter is tissue specific in transgenic mice.Molecular and cellular biology · 1989Article
- Evidence that introns arose at proto-splice sites.The EMBO journal · 1989Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complete nucleotide sequence of a genomic clone encoding the mouse skeletal alpha-actin gene has been determined. This single-copy gene codes for a protein identical in primary sequence to the rabbit skeletal alpha-actin. It has a large intron in the 5'-untranslated region 12 nucleotides upstream from the initiator ATG and five small introns in the coding region at codons specifying amino acids 41/42, 150, 204, 267, and 327/328. These intron positions are identical to those for the corresponding genes of chickens and rats. Similar to other skeletal alpha-actin genes, the nucleotide sequence codes for two amino acids, Met-Cys, preceding the known N-terminal Asp of the mature protein. Comparison of the nucleotide sequences of rat, mouse, chicken, and human skeletal muscle alpha-actin genes reveals conserved sequences (some not previously noted) outside of the protein-coding region. Furthermore, several inverted repeat sequences, partially within these conserved regions, have been identified. These sequences are not present in the vertebrate cytoskeletal beta-actin genes. The strong conservation of the inverted repeat sequences suggests that they may have a role in the tissue-specific expression of skeletal alpha-actin genes.
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